| Title: | High diversity of dietary flavonoid intake is associated with a lower risk of all-cause mortality and major chronic diseases |
| Journal: | Nature Food |
| Published: | 2 Jun 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40456886/ |
| DOI: | https://doi.org/10.1038/s43016-025-01176-1 |
| URL: | https://www.nature.com/articles/s43016-025-01176-1.pdf |
Publication 15102
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Abstract
Higher habitual intakes of dietary flavonoids have been linked with a lower risk of all-cause mortality and major chronic disease. Yet, the contribution of diversity of flavonoid intake to health outcomes remains to be investigated. Here, using a cohort of 124,805 UK Biobank participants, we show that participants who consumed the widest diversity of dietary flavonoids, flavonoid-rich foods and/or specific flavonoid subclasses had a 6-20% significantly lower risk of all-cause mortality and incidence of cardiovascular disease, type 2 diabetes, cancer, respiratory disease and neurodegenerative disease. Furthermore, we report that both quantity and diversity of flavonoids are independent predictors of mortality and several chronic diseases, suggesting that consuming a higher quantity and wider diversity is better for longer-term health than either component alone. These findings suggest that consuming several different daily servings of flavonoid-rich foods or beverages, such as tea, berries, apples, oranges or grapes, may lower risk of all-cause mortality and chronic disease.</p>
16 Keywords
- Aged
- Cardiovascular Diseases
- Chronic Disease
- Cohort Studies
- Diabetes Mellitus, Type 2
- Diet
- Female
- Flavonoids
- Humans
- Male
- Middle Aged
- Mortality
- Neoplasms
- Neurodegenerative Diseases
- Risk Factors
- United Kingdom
10 Authors
- Benjamin H. Parmenter
- Alysha S. Thompson
- Nicola P. Bondonno
- Amy Jennings
- Kevin Murray
- Aurora Perez-Cornago
- Jonathan M. Hodgson
- Anna Tresserra-Rimbau
- Tilman Kühn
- Aedín Cassidy
1 Application
| Application ID | Title |
|---|---|
| 64426 | Dietary factors in relation to risks of major chronic diseases and mortality |
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