| Title: | The Brain Care Score and its associations with cardiovascular disease and cancer |
| Journal: | Family Practice |
| Published: | 4 Jun 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40464807/ |
| DOI: | https://doi.org/10.1093/fampra/cmaf034 |
| URL: | https://academic.oup.com/fampra/article-pdf/42/4/cmaf034/63431536/cmaf034.pdf |
Publication 15074
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: The Brain Care Score (BCS) was developed in partnership with patients and practitioners to convey actionable knowledge to individuals everywhere that can motivate change in health-related behaviors and thereby reduce the risk of dementia, stroke, and late-life depression (LLD). Because diseases outside the brain share modifiable risk factors with dementia, stroke, and LLD, we investigated the associations of the BCS with other common age-related diseases, including cardiovascular disease (CVD) and cancer.</p>
METHODS: Among all UK Biobank (UKB) participants with complete BCS data, we performed Cox proportional hazard regression analyses between the BCS at baseline and incident CVD (ischemic heart disease, stroke, and heart failure) and the three most common cancer types (lung, colorectal, and breast cancer), adjusted for sex and stratified by age.</p>
RESULTS: Among 416 370 UKB participants (mean age: 57 years; 54% female), 33 944 cases of CVD (8.8%) and 16 090 cases of cancer (4.0%) were identified over a median follow-up of 12.5 years. A 5-point higher BCS at baseline was associated with a lower incidence of CVD (hazard ratio [HR]: 0.57 [95% confidence interval {95% CI}: 0.55-0.59]) and lower incidence of the three most common cancer types (HR: 0.69 [95% CI: 0.66-0.72]).</p>
CONCLUSIONS: A higher BCS at baseline is associated with a lower incidence of CVD and three cancer types. Although developed specifically as an actionable tool to guide individuals in reducing their risk of common age-related brain diseases, we show that it may also offer ancillary benefits, providing a single place to start for guiding individuals toward improving their chances of healthy aging more generally.</p>
13 Keywords
- Aged
- Cardiovascular Diseases
- Dementia
- Depression
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Neoplasms
- Proportional Hazards Models
- Risk Factors
- United Kingdom
15 Authors
- Jasper R Senff
- Cyprien A Rivier
- Reinier Tack
- Benjamin Y Q Tan
- Tamara N Kimball
- Hens Bart Brouwers
- Amy Newhouse
- Gregory Fricchione
- Rudolph E Tanzi
- Nirupama Yechoor
- Zeina Chemali
- Christopher D Anderson
- Jonathan Rosand
- Guido J Falcone
- Sanjula Singh
1 Application
| Application ID | Title |
|---|---|
| 58743 | Genetic and non-genetic determinants of cardiovascular disease, cerebrovascular disease, and aging. |
Enabling scientific discoveries that improve human health