| Title: | Association between functional gastrointestinal disorders and Parkinson's disease in a prospective cohort study |
| Journal: | npj Parkinson's Disease |
| Published: | 4 Jun 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40467598/ |
| DOI: | https://doi.org/10.1038/s41531-025-01000-4 |
| URL: | https://www.nature.com/articles/s41531-025-01000-4.pdf |
Publication 15072
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Abstract
The influence of functional gastrointestinal disorders (FGIDs) on the onset of Parkinson's disease (PD) remains unclear. Therefore, in this study, we examined the effect of FGIDs and their subtypes on the PD onset. In Cox proportional hazards model, FGIDs significantly increased the risk of PD incidence [hazard ratio (HR) = 1.74, 95% confidence interval (CI) = 1.30-2.33]. Similar results were also observed for functional dyspepsia (HR = 1.71, 95% CI = 1.17-2.52) and other functional intestinal disorders (other FIDs) (HR = 1.67, 95% CI = 1.00-2.78). Mediation analyses revealed that mental health scores mediated 10.00% and 8.32% of the association between FGIDs and functional dyspepsia and PD development. This cohort study discovered that FGIDs increase the risk of developing PD. Similar effects can also be observed in functional dyspepsia and other FIDs and mental health mediates part of the effect of FGIDs and functional dyspepsia on PD.</p>
9 Authors
- Yixiang Lin
- Haoling Xu
- Jiayi Zheng
- Tianxin Lin
- Minhui Wang
- Tingting Huang
- Fabin Lin
- Qinyong Ye
- Guoen Cai
1 Application
| Application ID | Title |
|---|---|
| 94166 | Causal relationships between lifestyle and environment exposures and neurodegenerative and cerebrovascular diseases |
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