| Title: | Long-term intra-individual reproducibility of heart rate dynamics during exercise and recovery in the UK Biobank cohort |
| Journal: | PLOS ONE |
| Published: | 5 Sep 2017 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/28873397/ |
| DOI: | https://doi.org/10.1371/journal.pone.0183732 |
| URL: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0183732&type=printable |
Publication 1503
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Abstract
BACKGROUND: The heart rate (HR) response to exercise provides useful information about the autonomic function and has prognostic value, but its reproducibility over a long period of time, a critical requirement for using it as a clinical biomarker, is undetermined.</p>
AIM: To determine the intra-individual reproducibility of HR dynamics during sub-maximum exercise and one minute recovery.</p>
METHODS: 1187 individuals from the Cardio physical fitness assessment test of the UK Biobank repeated a standard exercise stress test twice (recall time 34.2 ± 2.8 months) and were prospectively studied.</p>
RESULTS: 821 individuals complied with inclusion criteria for reproducibility analysis, including peak workload differences between assessments ≤10 W. Intra-individual correlation between HR profile during the first and the second assessment was very high and higher than inter-individual correlation (0.92±0.08 vs 0.87±0.11, p<0.01). Intra-individual correlation of indices describing HR dynamics was: ρ = 0.81 for maximum HR during exercise; ρ = 0.71 for minimum HR during recovery; ρ = 0.70 for HR changes during both exercise and recovery; Intra-individual correlation was higher for these indices of HR dynamics than for resting HR (ρ = 0.64). Bland-Altman plots demonstrated good agreement between HR indices estimated during the first and second assessment. A small but consistent bias was registered for all repeated measurements. The intra-individual consistency of abnormal values was about 60-70%.</p>
CONCLUSIONS: The HR dynamics during exercise and recovery are reproducible over a period of 3 years, with moderate to strong intra-individual reproducibility of abnormal values.</p>
4 Authors
- Michele Orini
- Andrew Tinker
- Patricia B. Munroe
- Pier D. Lambiase
1 Application
| Application ID | Title |
|---|---|
| 8256 | Understanding genetic influences in the response of the cardiac electrical system to exercise |
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