| Title: | Association of handgrip strength with aortic stenosis among adults aged 60 years and older: evidence from the 157097 UK Biobank participants. |
| Journal: | Journal of Geriatric Cardiology |
| Published: | 1 Nov 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39734654/ |
| DOI: | https://doi.org/10.26599/1671-5411.2024.11.003 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11672353 |
Publication 14587
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Abstract
Objective: To examine the association of handgrip strength with aortic stenosis incidence among adults aged 60 years and older.</p>
Methods: We conducted a cohort study using the UK Biobank data to assess the relationship between handgrip strength and incident aortic stenosis in individuals aged 60 years and older. Handgrip strength was measured using a Jamar J00105 hydraulic hand dynamometer. Adjusted Cox proportional hazards regression models were conducted to assess the association between handgrip strength and incident aortic stenosis.</p>
Results: We included 157,097 UK Biobank participants (78,151 women and 78,946 men) in our study, with mean age of 64 ± 2.9 years. During a median follow-up of 8.1 (7.4-8.8) years, 1543 (1.0%) participants developed incident aortic stenosis. Compared with those with the lowest handgrip strength (tertile 1), the adjusted hazard ratios (95% confidence interval) of incident aortic stenosis in the middle (tertile 2) and the highest (tertile 3) were 0.86 (0.77-0.97) and 0.76 (0.67-0.87), respectively.</p>
Conclusions: Higher handgrip strength was associated with lower risk of developing aortic stenosis in older adults. Future studies warrant preventive strategies for older adults with lower handgrip strength.</p>
7 Authors
- Cheng-Xiang Song
- Qing Li
- Cong-Ying Xia
- Lu Long
- Xiao-Xi Zeng
- Jun-Li Li
- Mao Chen
1 Application
| Application ID | Title |
|---|---|
| 54803 | Deciphering complex traits - phenotypic and genetic associations between traits in the UK Biobank Cohort |
Enabling scientific discoveries that improve human health