| Title: | Events in Early Life are Associated with Female Reproductive Ageing: A UK Biobank Study |
| Journal: | Scientific Reports |
| Published: | 20 Apr 2016 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/27094806/ |
| DOI: | https://doi.org/10.1038/srep24710 |
| URL: | https://www.nature.com/articles/srep24710.pdf |
Publication 1457
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Abstract
The available oocyte pool is determined before birth, with the majority of oocytes lost before puberty. We hypothesised that events occurring before birth, in childhood or in adolescence ('early-life risk factors') could influence the size of the oocyte pool and thus the timing of menopause. We included cross-sectional data from 273,474 women from the UK Biobank, recruited in 2006-2010 from across the UK. We analysed the association of early menopause with events occurring before adulthood in 11,781 cases (menopause aged under 45) and 173,641 controls (menopause/pre-menopausal at ≥45 years), in models controlling for potential confounding variables. Being part of a multiple birth was strongly associated with early menopause (odds ratio = 1.42, confidence interval: 1.11, 1.82, P = 8.0 × 10−9, fully-adjusted model). Earlier age at menarche (odds ratio = 1.03, confidence interval: 1.01, 1.06, P = 2.5 × 10−6) and earlier year of birth were also associated with EM (odds ratio = 1.02, confidence interval: 1.00, 1.04, P = 8.0 × 10−6). We also confirmed previously reported associations with smoking, drinking alcohol, educational level and number of births. We identified an association between multiple births and early menopause, which connects events pre-birth, when the oocyte pool is formed, with reproductive ageing in later life.</p>
6 Authors
- Katherine S. Ruth
- John R. B. Perry
- William E. Henley
- David Melzer
- Michael N. Weedon
- Anna Murray
1 Application
| Application ID | Title |
|---|---|
| 871 | Genetic factors associated with being at different extremes of the reproductive lifespan |
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