| Title: | Life's Essential 8 and cardiovascular disease in women with a history of adverse pregnancy outcomes |
| Journal: | European Journal of Preventive Cardiology |
| Published: | 31 Jan 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39887026/ |
| DOI: | https://doi.org/10.1093/eurjpc/zwaf021 |
Publication 14459
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Abstract
AIMS: To assess whether better cardiovascular health is associated with a lower long-term risk of CVD in women with a history of adverse pregnancy outcomes (APOs).</p>
METHODS: Using data from the UK Biobank prospective cohort, we included 2,263 participants with prior APOs and 107,260 participants without prior APOs. Life's Essential 8 (LE8) score was assessed at baseline. Multivariable-adjusted Cox models were used to estimate the associations between LE8 score and CVD events.</p>
RESULTS: Over a median 13.5 years of follow-up, 11,134 incident CVD events were documented. Among women with prior APOs, the incidence of total CVD was significantly lower in the top tertile compared to the bottom tertile, with a HR (95% CI) of 0.43 (0.29, 0.65). A similar trend was observed in women without APOs, with an HR (95% CI) of 0.55 (0.53, 0.58). With respect to the individual CVD outcomes, among women with APOs, only the associations with coronary heart disease, HR (95% CI) for T3 vs T1: 0.30 (0.17, 0.55) and atrial fibrillation, 0.47 (0.24, 0.91), achieved statistical significance. Women with high LE8 score and prior APOs had a similar long-term cardiovascular risk compared to women with high LE8 score and no prior APOs, 0.95 (0.63, 1.44).</p>
CONCLUSIONS: Among women with a history of APOs, better cardiovascular health as assessed using LE8 was associated with a significantly lower incidence of CVD, particularly coronary heart disease and atrial fibrillation. The excess risk associated with APOs appears to be attenuated among those with a high LE8 score.</p>
15 Authors
- Haozhang Chen
- Ruyi Li
- Sen Liu
- Shiyu Zhao
- Tianyu Guo
- Shufan Tian
- Jiale Zhong
- Zijun Tang
- Zhenghao Ge
- Jiawei Xia
- Tingting Geng
- Xiongfei Pan
- An Pan
- Frank Qian
- Gang Liu
1 Application
| Application ID | Title |
|---|---|
| 109546 | Associations of environmental and genetic factors with the risks of incidence and progression of cardiometabolic diseases |
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