| Title: | Causal Association Between Chronic Inflammatory Arthropathies and Sarcopenia and the Mediation Role of Inflammatory Factors |
| Journal: | International Journal of Rheumatic Diseases |
| Published: | 2 Feb 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39895240/ |
| DOI: | https://doi.org/10.1111/1756-185x.70100 |
Publication 14450
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Abstract
BACKGROUND: Although chronic inflammatory arthropathies (CIA) are associated with sarcopenia, sarcopenia plays a role in their pathogenesis remains unknown. This study investigated the causal relationship between sarcopenia and CIA and to identify potential mediating factors.</p>
METHODS: We examined data from 458 910 participants in the UK Biobank to analyze the association between sarcopenia-related traits and CIA. Associations between hand-grip strength, muscle mass, walking pace, and CIA were analyzed using Cox regression models. Then, we performed a mediation analysis to explore the underlying mechanisms.</p>
RESULTS: Individuals with low hand-grip strength exhibited a 1.88-fold (95% CI 1.73-2.05), 2.22-fold (95% CI 2.02-2.45), and 1.36-fold (95% CI 1.32-1.41) increased risk of rheumatoid arthritis (RA), spondyloarthritis (SpA), and osteoarthritis (OA), respectively. The HRs for sarcopenia were 1.64 (95% CI 1.15-2.32) for RA, 1.83 (95% CI 1.21-2.77) for SpA, and 1.26 (95% CI 1.09-1.45) for OA. Additionally, individuals with a slow walking pace exhibited a 1.83-fold (95% CI 1.66-2.02), 3.58-fold (95% CI 3.25-3.95), and 1.82-fold (95% CI 1.77-1.88) increased risk of RA, SpA, and OA, respectively. Furthermore, we identified inflammatory markers as possible mediators of the causal effects of low hand-grip strength on the development of CIA.</p>
CONCLUSIONS: Our findings suggest that sarcopenia is independently associated with an increased risk of CIA, which is partially mediated by inflammation factors.</p>
17 Keywords
- Adult
- Aged
- Arthritis, Rheumatoid
- Female
- Hand Strength
- Humans
- Inflammation Mediators
- Male
- Mediation Analysis
- Middle Aged
- Osteoarthritis
- Risk Assessment
- Risk Factors
- Sarcopenia
- Spondylarthritis
- United Kingdom
- Walking Speed
6 Authors
- Yanyan Qian
- Xiaowei Wang
- Chen Zhu
- Qiang Tong
- Jianzheng Zhang
- Shengjie Zhao
1 Application
| Application ID | Title |
|---|---|
| 106397 | Analysis of risk factors for hematopoietic and immune system aging and their association with immune diseases and cancer |
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