| Title: | Circulating fatty acid profiles impact total, cardiovascular disease, and cancer mortality in a population-based prospective cohort study |
| Journal: | Clinical Nutrition |
| Published: | 3 Feb 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39965263/ |
| DOI: | https://doi.org/10.1016/j.clnu.2025.01.034 |
Publication 14448
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Abstract
BACKGROUND: Evidence linking circulating fatty acids (FAs) to mortality from age-related chronic diseases was limited and inconsistent. We aimed to investigate the associations of plasma FAs with total, cardiovascular disease (CVD), and cancer mortality and explore the potential mechanism.</p>
METHODS: 117,871 individuals were prospectively followed in the UK Biobank. Circulating FAs were measured by a high-throughput NMR-based metabolic platform. Causes and dates of death were collected from death certificates according to the code of International Statistical Classification of Diseases (ICD-10).</p>
RESULTS: Over a median follow-up of 11.9 years, 7805 (6.6 %) deaths occurred. Plasma saturated FAs (SFAs) were positively associated with total mortality risk while plasma polyunsaturated FAs (PUFAs) exhibited an inverse association. For cause-specific mortality, circulating PUFAs, linoleic acid (LA), and n-3 PUFAs were associated with 34 %, 30 %, and 37 % lower risk of CVD mortality, respectively. Moreover, plasma n-3 PUFAs were related to a 24 % lower risk of cancer mortality. However, circulating non-LA n-6 PUFAs were associated with 11 % and 22 % higher risk of total and cancer mortality, respectively. Serum levels of C-reactive protein (CRP) and apolipoprotein A (ApoA) had significant mediation effects on these associations. Additionally, the inverse association of plasma n-6 PUFAs with total mortality only existed among carriers of the GG genotype at rs16966952 and the inverse association of plasma PUFAs with CVD mortality was only observed among TT genotype carriers at rs174547.</p>
CONCLUSIONS: Circulating PUFAs, particularly n-3 PUFAs and LA, were inversely related to premature death from chronic diseases and longevity. Inflammatory and lipid metabolism partially explained these associations. Genetic interactions with rs16966952 and rs174547 further modified these associations.</p>
13 Keywords
- Adult
- Aged
- Cardiovascular Diseases
- Fatty Acids
- Fatty Acids, Unsaturated
- Female
- Humans
- Male
- Middle Aged
- Neoplasms
- Prospective Studies
- Risk Factors
- United Kingdom
12 Authors
- Xiaohui Liu
- Yang Ao
- Yin Li
- Haoyin Liu
- Hao Ye
- Xiaoran Song
- Xunan Lin
- Youyou Zheng
- Xuzhi Wan
- Pan Zhuang
- Yu Zhang
- Jingjing Jiao
1 Application
| Application ID | Title |
|---|---|
| 47365 | Dietary patterns and genetic predisposition to obesity, type 2 diabetes, and cardiovascular disease. |
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