| Title: | High-sensitivity C-reactive protein and risk of retinal artery occlusion and ischaemic stroke: a cross-cohort study |
| Journal: | British Journal of Ophthalmology |
| Published: | 4 Feb 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39904581/ |
| DOI: | https://doi.org/10.1136/bjo-2023-325044 |
Publication 14439
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Abstract
AIMS: Previous studies have suggested an association between retinal artery occlusion (RAO) and ischaemic stroke (IS), both associated with elevated inflammatory factors. However, the role of high-sensitivity C-reactive protein (hs-CRP) in the sequential onset of these two diseases is still unclear. Based on this evidence, we evaluated the association of hs-CRP with RAO and IS.</p>
METHODS: We examined hs-CRP from both the large multicentre cohort study UK Biobank and Chinese Retinal Artery Occlusion study. Cox proportional hazard models were used to study the association of hs-CRP with incident RAO and IS during the long-term follow-up in the UK Biobank. Logistic regression analysis was employed to assess the cross-sectional relationship between hs-CRP with RAO and IS in the Chinese cohort. A restricted cubic spline (RCS) approach was employed to evaluate potential non-linear associations of hs-CRP with IS.</p>
RESULTS: After exclusions, the analysis included 459 188 participants from the UK and 338 participants from China. Over a median follow-up of 12.2 years, 136 cases of incident RAO and 3206 cases of incident IS events were recorded in the UK Biobank. After multivariable adjustment, higher hs-CRP (per 10 mg/L) level was associated with increased risks of RAO (HR: 1.34, 95% CI: 1.01 to 1.76) and IS (HR: 1.24, 95% CI: 1.17 to 1.33). RCS analysis revealed a significant non-linear relationship between hs-CRP levels and incident IS (Pnon-linear<0.001). Furthermore, RAO patients with higher hs-CRP levels were more likely to be combined with IS (2.81 mg/L vs 10.14 mg/L, p<0.001). In the Chinese cohort, the association between hs-CRP with RAO and IS was further confirmed. Higher hs-CRP (per 1 mg/L) level was associated with increased risks of RAO (OR: 1.43, 95% CI: 1.15 to 1.78) and IS (OR: 1.13, 95% CI: 1.03 to 1.24).</p>
CONCLUSIONS: Our findings underscore hs-CRP as a robust risk factor for both RAO and IS. Controlling hs-CRP levels might reduce the incidence of RAO and secondary stroke.</p>
16 Authors
- Yaxin Wang
- Xiayin Zhang
- Anyi Liang
- Yongyi Niu
- Daiyu Chen
- Zijing Du
- Wei Wu
- Feng Zhang
- Guanrong Wu
- Ying Fang
- Xianwen Shang
- Zhuoting Zhu
- Yijun Hu
- Xiangjun Chen
- Honghua Yu
- Lidan Hu
1 Application
| Application ID | Title |
|---|---|
| 86091 | Regulators of the association between ocular disorders and systemic diseases. |
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