| Title: | Associations of cachexia and frailty with amyotrophic lateral sclerosis |
| Journal: | Scientific Reports |
| Published: | 5 Feb 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39910275/ |
| DOI: | https://doi.org/10.1038/s41598-025-89080-3 |
Publication 14437
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
In the present study, we investigated the associations of cachexia (loss of muscle, weight and fat) and frailty (loss of weight and muscle) status with the risk of developing amyotrophic lateral sclerosis, because these specific terms are rarely used in this research area. In this prospective study, we extracted cachexia and frailty status from the UK Biobank cohort to study the associations of these conditions (as determined via international classification of disease-10 codes) with amyotrophic lateral sclerosis. There was a greater risk of developing amyotrophic lateral sclerosis among individuals with cachexia and frailty status after adjusting for age, sex, income (pounds), body mass index, UK Biobank centers and smoking status. Among individuals with frailty status: a grip strength of < 21 kg, a slow walking speed, and exhaustion (more than half the days or nearly every day) increase the risk of developing amyotrophic lateral sclerosis. We believe that studying cachexia and frailty status can be used to help define and treat amyotrophic lateral sclerosis.</p>
13 Keywords
- Aged
- Amyotrophic Lateral Sclerosis
- Body Mass Index
- Cachexia
- Female
- Frailty
- Hand Strength
- Humans
- Male
- Middle Aged
- Prospective Studies
- Risk Factors
- United Kingdom
7 Authors
- Tracy L. Peters
- Weihong Qiu
- Haomin Yang
- Wuqing Huang
- Yizhen Hu
- Zhangyu Zou
- Weimin Ye
1 Application
| Application ID | Title |
|---|---|
| 61083 | Uncover the genetic and phenotypic background for the disease network influencing women's life course health |
Enabling scientific discoveries that improve human health