| Title: | Behavioral Monitoring in Transient Ischemic Attack and Stroke Patients: Exploratory Micro- and Macrostructural Imaging Insights for Identifying Post-Stroke Depression with Accelerometers in UK Biobank |
| Journal: | Sensors |
| Published: | 5 Feb 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39943601/ |
| DOI: | https://doi.org/10.3390/s25030963 |
Publication 14434
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Abstract
To examine the association between post-stroke depression (PSD) and macrostructural and microstructural brain measures, and to explore whether changes in accelerometer-measured physical activity (PA) are associated with PSD, we conducted an exploratory study in UK Biobank with dementia-free participants diagnosed with at least one prior stroke. Eligible participants (n = 1186) completed an MRI scan. Depression was classified based on positive depression screening scores (PHQ-2 ≥ 3). Multivariate linear regression models assessed the relationships between depression and structural and diffusion measures generated from brain MRI scans. Logistic regression models were used to examine the relationship between accelerometer-measured daily PA and future depression (n = 367). Depression was positively associated with total white matter hyperintensities (WMHs) volume (standardized β [95% CI]-0.1339 [0.012, 0.256]; FDR-adjusted p-value-0.039), periventricular WMHs volume (standardized β [95% CI]-0.1351 [0.020, 0.250]; FDR-adjusted p-value-0.027), and reduced MD for commissural fibers (standardized β [95% CI]--0.139 [-0.255, -0.024]; adjusted p-value-0.045). The odds of depression decreased by 0.3% for each daily minute spent in objectively measured light PA, while each minute spent in sleep from midnight to 6:00 AM was associated with a 0.9% decrease in the odds of depression. This early-stage analysis using a population cohort offers a scientific rationale for researchers using multimodal data sources to investigate the heterogenous nature of PSD and, potentially, identify stroke patients at risk of poor outcomes.</p>
15 Keywords
- Accelerometry
- Aged
- Biological Specimen Banks
- Brain
- Depression
- Exercise
- Female
- Humans
- Ischemic Attack, Transient
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Stroke
- UK Biobank
- United Kingdom
4 Authors
- Stephanie J. Zawada
- Ali Ganjizadeh
- Bart M. Demaerschalk
- Bradley J. Erickson
1 Application
| Application ID | Title |
|---|---|
| 91159 | The association of physical activity with changes in brain volume and carotid artery stiffness in patients at risk for stroke |
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