| Title: | Healthy lifestyle reduces cardiovascular risk in women with genetic predisposition to hypertensive disorders of pregnancy |
| Journal: | Nature Communications |
| Published: | 8 Feb 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39920105/ |
| DOI: | https://doi.org/10.1038/s41467-025-56107-2 |
Publication 14420
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Abstract
The genetic risk for hypertensive disorders of pregnancy is linked with the development of atherosclerotic cardiovascular disease. However, the effects of lifestyle and metabolic syndrome on atherosclerotic cardiovascular disease have not been evaluated. Here, we assess the long-term association between these factors and atherosclerotic cardiovascular disease in women with genetic risk for hypertensive disorders of pregnancy. We evaluate the genetic risk for hypertensive disorders of pregnancy using a genome-wide polygenic risk score derived from a large-scale GWAS. The incidence of atherosclerotic cardiovascular disease is evaluated according to genetic risk, lifestyle, and metabolic syndrome. Individuals with a very high genetic risk for hypertensive disorders of pregnancy have a 53.0% higher chance of developing atherosclerotic cardiovascular disease than those with a low genetic risk. However, the risk of developing atherosclerotic cardiovascular disease is reduced by up to 64.6% through the maintenance of an ideal metabolic syndrome status and a healthy lifestyle in the high genetic risk group (top 20%), and by up to 65.4% in the low genetic risk group (bottom 20%). These findings emphasize that maintaining a healthy lifestyle in women is equally effective at reducing the risk of atherosclerotic cardiovascular disease independent of genetic risk for hypertensive disorders of pregnancy.</p>
12 Keywords
- Adult
- Atherosclerosis
- Cardiovascular Diseases
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Healthy Lifestyle
- Humans
- Hypertension, Pregnancy-Induced
- Metabolic Syndrome
- Pregnancy
- Risk Factors
14 Authors
- Sang-Hyuk Jung
- Haemin Kim
- Young Mi Jung
- Manu Shivakumar
- Brenda Xiao
- Jaeyoung Kim
- Beomjin Jang
- Jae-Seung Yun
- Hong-Hee Won
- Chan-Wook Park
- Joong Shin Park
- Jong Kwan Jun
- Dokyoon Kim
- Seung Mi Lee
1 Application
| Application ID | Title |
|---|---|
| 68416 | The effect of genetic variants on pregnancy complications and its long term health outcomes |
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