| Title: | Plant-based dietary patterns, genetic risk, proteome, and lung cancer risk: a large prospective cohort study |
| Journal: | European Journal of Nutrition |
| Published: | 11 Feb 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39934487/ |
| DOI: | https://doi.org/10.1007/s00394-025-03606-z |
Publication 14412
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
PurposeWe aimed to examine the associations between plant-based dietary patterns, genetic risk, proteins, and lung cancer risk.Methods189,541 participants of the UK Biobank were included. The Cox proportional hazards models and restricted cubic splines were performed to assess the associations between overall plant-based diet index(PDI), healthy PDI (hPDI), and unhealthy PDI (uPDI) and lung cancer risk. Polygenic risk score (PRS) was constructed to assess its joint effect with PDIs on lung cancer risk. Mediation analysis was conducted to examine which proteins mediated the associations of PDIs with incident lung cancer.ResultsHigher PDI was significantly correlated with reduced lung cancer risk(HR:0.90, 95% CI: 0.85-0.96, per SD). An elevated uPDI showed a significant correlation with an increased lung cancer risk(HR:1.08, 95% CI: 1.01-1.15, per SD). Individuals with a combination of high PRS and low PDI (HR: 2.09 [95% CI: 1.48-2.95]) or high uPDI (HR: 1.86 [95% CI: 1.36-2.53]) exhibited a notably higher lung cancer risk compared to those with low PRS and a high PDI or low uPDI. 42 proteins mediated the effect of PDI on lung cancer risk, and the association between uPDI with lung cancer was mediated by 117 proteins. The number of proteins displaying pathway enrichment within the cytokine-cytokine receptor interaction was the highest of the proteins mediated the effect of associations of PDI and uPDI with lung cancer risk.ConclusionA higher PDI correlated with reduced lung cancer risk, while a higher uPDI correlated with an elevated lung cancer risk. Low PDI jointing with high genetic risk increased lung cancer risk. Proteins enriched in cytokine-cytokine receptor interaction may mediate the association between plant-based dietary patterns with lung cancer risk.</p>
16 Keywords
- Adult
- Aged
- Cohort Studies
- Diet, Vegetarian
- Dietary Patterns
- Female
- Genetic Predisposition to Disease
- Humans
- Lung Neoplasms
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Proteome
- Risk Factors
- United Kingdom
7 Authors
- Wenmin Zhu
- Ziwei Shi
- Xiaolong Yan
- Zhiqun Lei
- Qi Wang
- Lin Lei
- Sheng Wei
1 Application
| Application ID | Title |
|---|---|
| 88159 | Fine-mapping, genetic correlation and genetic risk prediction for complex traits in different populations |
Enabling scientific discoveries that improve human health