| Title: | Blood lipid profiles and mood disorders: A principal component analysis of UK Biobank data reveals distinct associations with depression and bipolar disorder |
| Journal: | Journal of Affective Disorders |
| Published: | 16 Feb 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39961445/ |
| DOI: | https://doi.org/10.1016/j.jad.2025.02.040 |
Publication 14390
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Abstract
BACKGROUND: Growing evidence suggests that lipid metabolism may play a crucial role in mood disorder pathophysiology, and the correlation between blood lipids and mood disorder remains further clarified.</p>
METHODS: This prospective, population-based cohort study utilized data from the UK Biobank. The study included 268,098 and 292,121 participants who had never been diagnosed with depression or bipolar disorder and who had complete data at both the baseline and follow-up points. A principal component analysis (PCA) was conducted on seven blood lipids, and the first three principal components (PCs) were derived. Cox regression analysis was employed to examine the correlation between the risk of mood disorders and the PCs. Multiplicative interaction and sensitivity analyses were also conducted. The relationship between blood lipids and neurological biomarkers was explored using Spearman's analysis.</p>
RESULTS: PC1, primarily reflecting levels of Apolipoprotein B (ApoB), cholesterol, and low-density lipoprotein cholesterol (LDL-C), showed a protective effect against depression, with HRs of 0.98 (95 % CI: 0.96,1.00) in the fully adjusted Cox regression model. In contrast, PC2, characterized by opposite loadings for triglycerides and high-density lipoprotein cholesterol (HDLC), was positively associated with the risk of depression and bipolar disorder.(HR = 1.03,95 % CI: 1.01,1.06; HR = 1.11, 95 % CI: 1.01,1.23). Increased PC2 level was related to a significant increase in bipolar disorder risk among participants with high genetic risk (genetic risk score > 90 %, HR = 1.22, 95 % CI: 1.02,1.46). Complicated correlations between blood lipids and serum neuroproteins were detected.</p>
CONCLUSION: These findings suggest complex associations between blood lipid profiles and the risk of depression and bipolar disorder.</p>
8 Authors
- Xiangliang Liu
- Yuguang Li
- Wang Yang
- Xinqiao Chen
- Fangqi Li
- Naifei Chen
- Hongmei Yin
- Jiuwei Cui
1 Application
| Application ID | Title |
|---|---|
| 176493 | Harnessing Multi-Omics and Multimodal Data to Decipher the Interplay Between Diet, Inflammation, Metabolic Dysregulation, and Progression of Chronic Diseases |
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