| Title: | Associations of long-term exposure to nitrogen oxides with all-cause and cause-specific mortality |
| Journal: | Nature Communications |
| Published: | 18 Feb 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39966376/ |
| DOI: | https://doi.org/10.1038/s41467-025-56963-y |
Publication 14380
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Abstract
Associations between long-term exposure to nitrogen oxides (NOx) and cause-specific mortality remain insufficiently explored. This study utilizes data from 502,040 participants registered in the UK Biobank. Time-varying Cox regression is used to estimate mortality risks associated with NOx. Cause-specific mortality risks, including non-accidental, accidental and 15 major disease categories across 103 subcategories, are assessed for each 10 μg/m3 increase in NOx. Positive associations are observed between NOx and mortality from all-cause (HR: 1.036; 95% CI: 1.024, 1.049) and non-accidental diseases (HR: 1.032; 95% CI: 1.019, 1.045). We further identify 20 specific diseases related to NOx, notably respiratory diseases, mental and behavioral disorders, and circulatory diseases, with generally linear exposure-response relationships. Sex and residential areas are potential modifiers of the observed associations. Our findings suggest long-term exposure to NOx may increase mortality risks from a range of diseases, emphasizing the urgent need for clean air policies to alleviate the health burden.</p>
14 Keywords
- Adult
- Aged
- Air Pollutants
- Air Pollution
- Cause of Death
- Environmental Exposure
- Female
- Humans
- Male
- Middle Aged
- Mortality
- Nitrogen Oxides
- Proportional Hazards Models
- United Kingdom
12 Authors
- Siru Yang
- Mengmeng Li
- Cui Guo
- Weeberb J. Requia
- Mohammad Javad Zare Sakhvidi
- Kaili Lin
- Qiongyu Zhu
- Zhaoyue Chen
- Peihua Cao
- Lei Yang
- Dan Luo
- Jun Yang
1 Application
| Application ID | Title |
|---|---|
| 95736 | Environmental exposure, genetic factors, and chronic diseases |
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