| Title: | Coffee consumption and cancer risk: a Mendelian randomisation study |
| Journal: | Clinical Nutrition |
| Published: | 25 Aug 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36067583/ |
| DOI: | https://doi.org/10.1016/j.clnu.2022.08.019 |
| URL: | http://www.clinicalnutritionjournal.com/article/S0261561422003132/pdf |
Publication 14136
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Abstract
BACKGROUND: Coffee contains many bioactive chemicals and associations with cancer have been reported in observational studies. In this Mendelian randomisation (MR) study we investigated the causal associations of coffee consumption with a broad range of cancers.</p>
MATERIALS AND METHODS: Twelve independent genetic variants proxied coffee consumption. Genetically-predicted risk of any cancer (59,647 cases) and 22 site-specific cancers was estimated in European-descent individuals in UK Biobank. Univariable and multivariable MR analyses were conducted.</p>
RESULTS: Genetically-predicted coffee consumption was not associated with risk of any cancer in the main analysis (OR 1.05, 95% CI 0.98-1.14, p = 0.183) but was associated with an increased risk of digestive system cancer (OR 1.28, 95% CI 1.09-1.51, p = 0.003), driven by a strong association with oesophageal cancer (OR 2.79, 95% CI 1.73-4.50, p = 2.5×10-5). This association was consistent after adjustment for genetically-predicted body mass index, smoking and alcohol consumption. There was no strong evidence supporting a causal relationship between genetically-predicted coffee consumption and the majority of cancers studied. However, genetically-predicted coffee consumption was associated with increased risk of multiple myeloma (OR 2.25, 95% CI 1.30-3.89, p = 0.004) and reduced ovarian cancer risk (OR 0.63, 95% CI 0.43-0.93, p = 0.020).</p>
CONCLUSIONS: This MR study provides strong support for a causal association of coffee consumption with oesophageal cancer, but not for the majority of cancer types, and the underlying mechanisms require investigation.</p>
8 Keywords
- Coffee
- Esophageal Neoplasms
- Female
- Humans
- Mendelian Randomization Analysis
- Ovarian Neoplasms
- Polymorphism, Single Nucleotide
- Risk Factors
7 Authors
- Paul Carter
- Shuai Yuan
- Siddhartha Kar
- Mathew Vithayathil
- Amy M Mason
- Stephen Burgess
- Susanna C Larsson
1 Application
| Application ID | Title |
|---|---|
| 29202 | Epidemiologic and genetic analyses of aging-associated diseases and mortality |
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