| Title: | Serum insulin-like growth factor-1, asthma, and lung function among British adults |
| Journal: | Annals of Allergy Asthma & Immunology |
| Published: | 11 Dec 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/33316372/ |
| DOI: | https://doi.org/10.1016/j.anai.2020.12.005 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7897263 |
Publication 13708
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Abstract
BACKGROUND: Insulin-like growth factor-1 (IGF-1) plays a key role in the pathogenesis of metabolic syndrome, which is in turn associated with asthma. Whether IGF-1 contributes to asthma causation or asthma severity is largely unknown.</p>
OBJECTIVE: To evaluate the relation between serum IGF-1 and asthma, asthma outcomes, and lung function in adults.</p>
METHODS: Cross-sectional study of 297,590 adults (aged 40-69 years) who participated in the United Kingdom Biobank, had no diagnosis of diabetes, and were not on insulin. Multivariable logistic or linear regression was used to analyze serum IGF-1 and physician-diagnosed asthma, current wheezing, asthma hospitalizations, and lung function measures (forced expiratory volume in 1 second [FEV1], forced vital capacity [FVC], and FEV1 to FVC ratio).</p>
RESULTS: Serum IGF-1 levels above the lowest quartile (Q1) were significantly associated with lower odds of asthma (adjusted odds ratio for fourth quartile [Q4] vs Q1 = 0.88; 95% confidence interval [CI], 0.85-0.91). Among the participants with asthma, IGF-1 levels above Q1 were significantly associated with lower odds of current wheezing (adjusted odds ratio for Q4 vs Q1 = 0.89; 95% CI, 0.83-0.96), but not with asthma hospitalizations. Serum IGF-1 was significantly and positively associated with FEV1 (b = 20.9 mL; 95% CI, 19.1-22.7) and FVC (b = 25.6 mL; 95% CI, 23.4-27.7), regardless of an asthma diagnosis; these associations were significant in men and women, with larger estimated effects in men.</p>
CONCLUSION: In a large study of British adults, higher serum IGF-1 levels were associated with lower odds of asthma and current wheezing and higher FEV1 and FVC. Our findings suggest potential beneficial effects of circulating IGF-1 on asthma and asthma outcomes in adults.</p>
15 Keywords
- Adult
- Aged
- Asthma
- Case-Control Studies
- Cross-Sectional Studies
- Female
- Hospitalization
- Humans
- Insulin-Like Growth Factor I
- Logistic Models
- Male
- Middle Aged
- Respiratory Function Tests
- Respiratory Sounds
- United Kingdom
5 Authors
- Yueh-Ying Han
- Qi Yan
- Wei Chen
- Erick Forno
- Juan C Celedón
1 Application
| Application ID | Title |
|---|---|
| 43252 | The prediction of asthma status using clinical and genetic variables |
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