| Title: | Cardiovascular risk according to genetic predisposition to gout, lifestyle and metabolic health across prospective European and Korean cohorts |
| Journal: | RMD Open |
| Published: | 8 Oct 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39379299/ |
| DOI: | https://doi.org/10.1136/rmdopen-2024-004552 |
Publication 13592
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Abstract
OBJECTIVE: Recent studies have reported that gout is associated with a risk of cardiovascular disease (CVD) later in life. However, the predictive value of genetic predisposition to gout combined with lifestyle habits for CVD risk remains unclear. This study aimed to examine the association between genetic predisposition to gout and lifestyle habits and the risk of developing CVD in two diverse prospective cohorts from different ancestries.</p>
METHODS: A total of 224 689 participants of European descent from the UK Biobank and 50 364 participants of East Asian descent from the Korean Genome and Epidemiology Study were included. The genetic risk for gout was assessed using a polygenic risk score (PRS) derived from a meta-genome-wide association study (n=444 533). The incident CVD risk was evaluated according to genetic risk, lifestyle and metabolic syndrome (MetS).</p>
RESULTS: Individuals at high genetic risk for gout had a higher risk of incident CVD than those with low genetic risk across ancestry. Notably, a reduction in CVD risk by up to 62% (HR 0.38; 95% CI 0.31 to 0.46; p <0.001) was observed in individuals at both low and high genetic risk for gout when they maintained ideal MetS and favourable lifestyle habits.</p>
CONCLUSIONS: Our findings indicate that a higher genetic risk of gout is significantly associated with an increased risk of CVD. Moreover, adherence to a favourable lifestyle can significantly reduce CVD risk, particularly in individuals with high genetic risk. These results underscore the potential of PRS-based risk assessment to improve clinical outcomes through tailored preventative strategies.</p>
20 Keywords
- Adult
- Aged
- Asian People
- Cardiovascular Diseases
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Gout
- Humans
- Life Style
- Male
- Metabolic Syndrome
- Middle Aged
- Multifactorial Inheritance
- Polymorphism, Single Nucleotide
- Prospective Studies
- Republic of Korea
- Risk Assessment
- Risk Factors
- White People
10 Authors
- Ki Won Moon
- Sang-Hyuk Jung
- Hyunsue Do
- Chang-Nam Son
- Jaeyoung Kim
- Yonghyun Nam
- Jae-Seung Yun
- Woong-Yang Park
- Hong-Hee Won
- Dokyoon Kim
Enabling scientific discoveries that improve human health