| Title: | Ultra-processed food, genetic risk, and the risk of cardiometabolic diseases and cardiometabolic multimorbidity: A prospective study |
| Journal: | Nutrition Metabolism and Cardiovascular Diseases |
| Published: | 17 Sep 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39443279/ |
| DOI: | https://doi.org/10.1016/j.numecd.2024.09.011 |
Publication 13552
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Abstract
BACKGROUND AND AIMS: This study aims to evaluate the impact of ultra-processed food (UPF) on type 2 diabetes (T2D), cardiovascular disease (CVD), hypertension, and cardiometabolic multimorbidity (CMM), and to explore the role of genetic susceptibility in these associations.</p>
METHODS AND RESULTS: 90 631 participants from the UK Biobank were included (collected between 2006 and 2010). The outcomes assessed included T2D, CVD, hypertension and CMM. The Cox proportional hazards model was used to evaluate their associations and the potential modification by genetic risk, which was estimated using the polygenic risk score (PRS). Participants with high UPF consumption had a higher risk of T2D, CVD, and CMM, with the adjusted hazard ratio (HR) of 1.36 (95 % confidence interval [CI]: 1.15, 1.61), 1.13 (95%CI: 1.03, 1.23), and 1.14 (95%CI: 1.05, 1.24), respectively. Those with high UPF consumption and high PRS for T2D, CVD, and hypertension had the highest risk of T2D (HR: 4.01; 95%CI: 2.83, 5.69), CVD (HR: 2.18; 95%CI: 1.86, 2.56), and hypertension (HR: 1.79; 95%CI: 1.61, 1.99), respectively. In participants with one cardiometabolic disease (CMD), those with high UPF consumption and high PRST2D or PRSCVD had the highest risk of developing CMM. A significant additive interaction was observed between PRST2D and UPF consumption on the risk of T2D.</p>
CONCLUSION: Our study underscored the importance of identifying individuals with high UPF consumption for targeted dietary interventions to mitigate the risk of CMDs and CMM, particularly among those with a high genetic risk of CMDs.</p>
20 Keywords
- Adult
- Aged
- Cardiometabolic Risk Factors
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Fast Foods
- Female
- Food Handling
- Food, Processed
- Genetic Predisposition to Disease
- Humans
- Hypertension
- Male
- Middle Aged
- Multimorbidity
- Phenotype
- Prospective Studies
- Risk Assessment
- Time Factors
- United Kingdom
7 Authors
- Jing Wang
- Tingting Chen
- Wenmin Zhu
- Ziwei Shi
- Xiaolong Yan
- Zhiqun Lei
- Qi Wang
1 Application
| Application ID | Title |
|---|---|
| 88159 | Fine-mapping, genetic correlation and genetic risk prediction for complex traits in different populations |
Enabling scientific discoveries that improve human health