| Title: | Association between alcohol consumption and incidence of dementia in current drinkers: linear and non-linear mendelian randomization analysis |
| Journal: | EClinicalMedicine |
| Published: | 5 Sep 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39290634/ |
| DOI: | https://doi.org/10.1016/j.eclinm.2024.102810 |
| URL: | http://dx.doi.org/10.1016/j.eclinm.2024.102810 |
Publication 13524
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Abstract
Background: Previous conventional epidemiological studies found a J-shape relationship between alcohol consumption and dementia, but this result was subject to confounding biases and reverse causation. Therefore, we aimed to investigate the potential linear or non-linear causal association between alcohol consumption and the incident risk of dementia in current drinkers.</p>
Methods: This study used data from the UK Biobank to investigate the relationship between alcohol consumption and dementia risk. 313,958 White British current drinkers, who were free of dementia during 2006-2010, were followed up until 2021. Alcohol consumption was self-reported and calculated according to the National Health Service guideline. The primary outcome was all-cause dementia identified through hospital and mortality records. We used multivariable Cox models with restricted cubic splines for conventional analysis and both non-linear and linear Mendelian Randomization (MR) analyses to assess causal relationships, employing a genetic score based on 95 SNPs identified from a meta-genome-wide association study of 941,280 people from Europe.</p>
Findings: 313,958 current drinkers consumed an average of 13.6 [IQR: 7.1-25.2] units/week alcohol (men averaged 20.2 [11.1-33.9] units/week and women 9.5 [5.3-16.7] units/week). During a mean follow-up of 13.2 years, 5394 (1.7%) developed dementia. Multivariable Cox model with restricted cubic spline functions identified a J-shaped relationship between alcohol consumption and dementia risk, with the lowest risk at 12.2 units/week. The non-linear MR failed to identify a significant non-linear causal relationship (p = 0.45). Both individual-level (HR: 2.22 95%CI [1.06-4.66]) and summary-level (1.89 [1.53-2.32]) linear MR analyses indicated that higher genetically predicted alcohol consumption increased dementia risk.</p>
Interpretation: This study identified a positive linear causal relationship between alcohol consumption and dementia among current drinkers. The J-shaped association found in conventional epidemiological analysis was not supported by non-linear MR analyses. Our findings suggested that there was no safe level of alcohol consumption for dementia.</p>
Funding: The Shenzhen Science and Technology Program and the Strategic Priority Research Program of Chinese Academy of Sciences.</p>
12 Authors
- Lingling Zheng
- Weiyao Liao
- Shan Luo
- Bingyu Li
- Di Liu
- Qingping Yun
- Ziyi Zhao
- Jia Zhao
- Jianhui Rong
- Zhiguo Gong
- Feng Sha
- Jinling Tang
1 Application
| Application ID | Title |
|---|---|
| 80476 | Risk factors and prognosis of common mental disorders |
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