| Title: | Sleep patterns, genetic susceptibility, and venous thromboembolism: A prospective study of 384,758 UK Biobank participants. |
| Journal: | PLOS ONE |
| Published: | 6 Sep 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39240854/ |
| DOI: | https://doi.org/10.1371/journal.pone.0309870 |
Publication 13522
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: Although healthy sleep patterns have been linked to a lower risk of cardiovascular disease in earlier research, it is unclear how beneficial they are for venous thromboembolism (VTE).</p>
AIM: This research aimed to examine the correlation between sleep patterns, genetic susceptibility, and VTE.</p>
METHODS: In the UK Biobank cohort, healthy sleep behaviors were defined as early chronotype, 7-8 hours of sleep each day, no snoring, infrequent insomnia, and infrequent daytime sleepiness. Each of the five criteria was given 1 point, creating a healthy sleep score ranging from 0 to 5. Cox proportional hazards regression models were utilized to examine the associations between genetic susceptibility, healthy sleep score and VTE.</p>
RESULTS: The UK Biobank study included 384,758 participants aged 56.6 ± 8.0 years. After a median of 11.9 years of follow-up, 8,885 (2.3%) participants were diagnosed with VTE. A healthy sleep score inversely affected VTE risk. For participants with a score of 5, the hazard ratio of VTE was 0.813 (95% confidence interval: 0.758-0.873, P<0.001) compared to those with a score ≤2. Early chronotype, sleeping 7-8 hours each day, infrequent insomnia, and infrequent daytime sleepiness were significantly associated with a 7.9%, 8.3%, 5.1%, and 20.7% lower risk of VTE, respectively. In addition, the correlation between sleep pattern and the incidence of VTE was consistent, regardless of genetic susceptibility (P for interaction = 0.366).</p>
CONCLUSIONS: Our secondary analysis of a large-scale prospectively gathered registry revealed that individuals with a healthy sleep pattern are significantly correlated with lower risk of developing VTE, irrespective of genetic susceptibility.</p>
15 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Female
- Genetic Predisposition to Disease
- Humans
- Male
- Middle Aged
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- Sleep
- UK Biobank
- United Kingdom
- Venous Thromboembolism
13 Authors
- Jiaxin Bai
- Ziyu Yang
- Yu Jia
- Jing Yu
- Wenli Jiang
- Yi Liu
- Fanghui Li
- Rui Zeng
- Zhi Wan
- Yi Lei
- Xiaoyang Liao
- Dongze Li
- Qian Zhao
1 Application
| Application ID | Title |
|---|---|
| 112111 | Multi-system diseases and death trajectory of metabolic dysfunction-associated fatty liver disease |
Enabling scientific discoveries that improve human health