| Title: | Shorter Leukocyte Telomere Length Is Associated with Increased Major Adverse Cardiovascular Events or Mortality in Patients with Essential Hypertension |
| Journal: | Journal of Cardiovascular Translational Research |
| Published: | 18 Oct 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39422841/ |
| DOI: | https://doi.org/10.1007/s12265-024-10558-y |
Publication 13416
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Abstract
The association between leukocyte telomere length (LTL) alteration and major adverse cardiovascular events (MACE) or mortality in patients with hypertension is still unclear. 20,034 patients with essential hypertension were enrolled from UK biobank. Multivariable COX regression models were performed to assess the association. LTL was shorter in hypertensive patients with MACE compared to those without MACE. Hypertensive patients in the lowest LTL quartile were at higher risk to develop MACE (adjusted HR 1.15 [95% CI 1.02-1.29], vs top LTL quartile, p-trend = 0.03). Similarly, shorter LTL was related with increased mortality (adjusted HR 1.18[95% CI 1.06-1.3], lowest vs top LTL quartile, p-trend < 0.001). This investigation demonstrated that shorter LTL is associated with increased risk of MACE or mortality in patients with essential hypertension, which indicates that LTL may be a potential predictor of prognosis or underlying therapeutic target for hypertension.Graphical AbstractThis study demonstrated that shorter LTL is associated with increased risk of MACE or mortality in patients with essential hypertension</p>
12 Authors
- Hongna Fu
- Yuanting Zhu
- Luyang Lin
- Peng Jiang
- Guoyi Cai
- Lijin Zeng
- Xinyu Li
- Yuchun Zhang
- Chunhao Li
- Hong Zhan
- Bo Zhang
- Zhen Yang
1 Application
| Application ID | Title |
|---|---|
| 92584 | Research on cardiovascular diseases, severe or acute diseases, chronic diseases and their related risk factors |
Enabling scientific discoveries that improve human health