| Title: | Healthy Lifestyle, Metabolic Signature, and Risk of Cardiovascular Diseases: A Population-Based Study |
| Journal: | Nutrients |
| Published: | 19 Oct 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39458547/ |
| DOI: | https://doi.org/10.3390/nu16203553 |
Publication 13412
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Abstract
BACKGROUND: Although healthy lifestyle has been linked with a reduced risk of cardiovascular diseases (CVDs), the potential metabolic mechanism underlying this association remains unknown.</p>
METHODS: We included 161,018 CVD-free participants from the UK Biobank. Elastic net regression was utilized to generate a healthy lifestyle-related metabolic signature. The Cox proportional hazards model was applied to investigate associations of lifestyle-related metabolic signature with incident CVDs, and mediation analysis was conducted to evaluate the potential mediating role of metabolic profile on the healthy lifestyle-CVD association. Mendelian randomization (MR) analysis was conducted to detect the causality.</p>
RESULTS: During 13 years of follow-up, 17,030 participants developed incident CVDs. A healthy lifestyle-related metabolic signature comprising 123 metabolites was established, and it was inversely associated with CVDs. The hazard ratio (HR) was 0.83 (95% confidence interval [CI]: 0.81, 0.84) for CVD, 0.83 (95% CI: 0.81, 0.84) for ischemic heart disease (IHD), 0.86 (95% CI: 0.83, 0.90) for stroke, 0.86 (95% CI: 0.82, 0.89) for myocardial infarction (MI), and 0.75 (95% CI: 0.72, 0.77) for heart failure (HF) per standard deviation increase in the metabolic signature. The metabolic signature accounted for 20% of the association between healthy lifestyle score and CVD. Moreover, MR showed a potential causal association between the metabolic signature and stroke.</p>
CONCLUSIONS: Our study revealed a potential link between a healthy lifestyle, metabolic signatures, and CVD. This connection suggests that identifying an individual's metabolic status and implementing lifestyle modifications may provide novel insights into the prevention of CVD.</p>
13 Keywords
- Adult
- Aged
- Cardiovascular Diseases
- Female
- Healthy Lifestyle
- Humans
- Male
- Mendelian Randomization Analysis
- Metabolome
- Middle Aged
- Proportional Hazards Models
- Risk Factors
- United Kingdom
11 Authors
- Yuhua Wang
- Fei Tian
- Zhengmin Qian
- Shanshan Ran
- Jingyi Zhang
- Chongjian Wang
- Lan Chen
- Dashan Zheng
- Michael G. Vaughn
- Maya Tabet
- Hualiang Lin
1 Application
| Application ID | Title |
|---|---|
| 69550 | Identifying the potential effects of environmental and other healthcare related factors influencing health outcomes, mediated by genetic variances |
Enabling scientific discoveries that improve human health