| Title: | Imaging genetics of language network functional connectivity reveals links with language-related abilities, dyslexia and handedness |
| Journal: | Communications Biology |
| Published: | 28 Sep 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/39342056/ |
| DOI: | https://doi.org/10.1038/s42003-024-06890-3 |
Publication 13366
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Abstract
Language is supported by a distributed network of brain regions with a particular contribution from the left hemisphere. A multi-level understanding of this network requires studying its genetic architecture. We used resting-state imaging data from 29,681 participants (UK Biobank) to measure connectivity between 18 left-hemisphere regions involved in multimodal sentence-level processing, as well as their right-hemisphere homotopes, and interhemispheric connections. Multivariate genome-wide association analysis of this total network, based on genetic variants with population frequencies >1%, identified 14 genomic loci, of which three were also associated with asymmetry of intrahemispheric connectivity. Polygenic dispositions to lower language-related abilities, dyslexia and left-handedness were associated with generally reduced leftward asymmetry of functional connectivity. Exome-wide association analysis based on rare, protein-altering variants (frequencies <1%) suggested 7 additional genes. These findings shed new light on genetic contributions to language network organization and related behavioural traits.</p>
14 Keywords
- Adult
- Aged
- Brain
- Brain Mapping
- Dyslexia
- Female
- Functional Laterality
- Genome-Wide Association Study
- Humans
- Language
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Nerve Net
11 Authors
- Jitse S. Amelink
- Merel C. Postema
- Xiang-Zhen Kong
- Dick Schijven
- Amaia Carrión-Castillo
- Sourena Soheili-Nezhad
- Zhiqiang Sha
- Barbara Molz
- Marc Joliot
- Simon E. Fisher
- Clyde Francks
1 Application
| Application ID | Title |
|---|---|
| 16066 | Genetics of brain asymmetry and language-related disorders |
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