| Title: | Unraveling the Link: How Air Pollution and Temperature Shape Ischemic Stroke Risk: A Prospective Study |
| Journal: | Earth Systems and Environment |
| Published: | 14 Oct 2024 |
| DOI: | https://doi.org/10.1007/s41748-024-00496-9 |
Publication 13231
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Abstract
The role of environmental factors in stroke has received public attention in the last few centuries, among which air quality and ambient temperature are the most common types. This study aimed to investigate the effects of long-term air pollution and ambient temperature on the occurrence of ischemic stroke by using the data from a large prospective population cohort (UK Biobank). The role of the interactions between air quality and ambient temperature in the occurrence of ischemic stroke was also explored. Cox proportional hazards regression with time-varying exposure were combined to investigate the effects of air pollutants [including particulate matter (PM2.5, PM2.5−10, PM10), and nitrogen oxides (NO2, NOx)], the mean and variability of seasonal temperatures, and their interactions on ischemic stroke. Pollutant concentrations were estimated using the Land Use Regression (LUR) model developed by the European Air Pollution Impact Cohort Research Project. A higher hazard ratio of incident ischemic stroke for 10 µg/m3 increase in PM2.5 (HR 1.54 [95% CI 1.20-1.95]), PM2.5−10 (1.05 [0.79-1.40]), PM10 (1.06 [0.93-1.22]), NO2 (1.04 [1.01-1.07]), and NOx (1.02 [1.00-1.04]) was observed, and the hazard ratio for 1 °C increase in Tsum, Twin, SDsum, SDwin was 0.95 (0.92-0.98), 0.93 (0.89-0.97), 1.52 (1.19-1.93) and 0.49 (0.36-0.67), respectively. A significant antagonistic effect between NO2 and summer temperature variability (P < 0.001) was also observed. Subgroup analyses showed that the combined effects of NO2 and summer temperature variability were stronger in older patients and participants with complications. Long-term exposure to various air pollutants, including PM2.5, NO2 and NOx, could lead to an increased risk of ischemic stroke. The interactions between NO2 and summer temperature variability were also associated with ischemic stroke, especially for older individuals and participants with complications. It is suggested to strengthen the publicity on the health risks of combined ambient temperature and air pollution events to protect the vulnerable populations against stroke.</p>
9 Authors
- Peng Fang
- Shuzi Ye
- Jiali Wang
- Yinyan Gao
- Yijuan Lin
- Siwen Li
- Irene Xinyin Wu
- Wenjie Dai
- Fang Xiao
1 Application
| Application ID | Title |
|---|---|
| 64555 | Interaction effect of physical activity and environmental factors on health outcomes in general populations |
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