| Title: | Higher habitual intakes of flavonoids and flavonoid-rich foods are associated with a lower incidence of type 2 diabetes in the UK Biobank cohort |
| Journal: | Nutrition & Diabetes |
| Published: | 22 May 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38778045/ |
| DOI: | https://doi.org/10.1038/s41387-024-00288-0 |
| URL: | https://www.nature.com/articles/s41387-024-00288-0.pdf |
| Citations: | 1 (1 in last 2 years) as of 8 Aug 2024 |
Publication 12015
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
AimTo examine the associations of a diet high in flavonoid-rich foods, as reflected by a "Flavodiet Score" (FDS), the major individual food contributors to flavonoid intake, and flavonoid subclasses with type 2 diabetes (T2D) risk in the UK Biobank cohort.Materials and methodsFlavonoid intakes were estimated from ≥2 dietary assessments among 113,097 study participants [age at enrolment: 56 ± 8 years; 57% female] using the U.S Department of Agriculture (USDA) databases. Multivariable Cox proportional hazards models were used to investigate associations between dietary exposures and T2D.ResultsDuring 12 years of follow-up, 2628 incident cases of T2D were identified. A higher FDS (compared to lower [Q4 vs. Q1]), characterised by an average of 6 servings of flavonoid-rich foods per day, was associated with a 26% lower T2D risk [HR: 0.74 (95% CI: 0.66-0.84), ptrend = <0.001]. Mediation analyses showed that lower body fatness and basal inflammation, as well as better kidney and liver function partially explain this association. In food-based analyses, higher intakes of black or green tea, berries, and apples were significantly associated with 21%, 15%, and 12% lower T2D risk. Among individual flavonoid subclasses, 19-28% lower risks of T2D were observed among those with the highest, compared to lowest intakes.ConclusionsA higher consumption of flavonoid-rich foods was associated with lower T2D risk, potentially mediated by benefits to obesity/sugar metabolism, inflammation, kidney and liver function. Achievable increases in intakes of specific flavonoid-rich foods have the potential to reduce T2D risk.</p>
9 Authors
- Alysha S. Thompson
- Amy Jennings
- Nicola P. Bondonno
- Anna Tresserra-Rimbau
- Benjamin H. Parmenter
- Claire Hill
- Aurora Perez-Cornago
- Tilman Kühn
- Aedín Cassidy
1 Application
| Application ID | Title |
|---|---|
| 64426 | Dietary factors in relation to risks of major chronic diseases and mortality |
Enabling scientific discoveries that improve human health