| Title: | Catch me if you can: signal localization with knockoff e-values |
| Journal: | Journal of the Royal Statistical Society Series B (Statistical Methodology) |
| Published: | 14 Jun 2024 |
| DOI: | https://doi.org/10.1093/jrsssb/qkae042 |
Publication 11855
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Abstract
Abstract We consider problems where many, somewhat redundant, hypotheses are tested and we are interested in reporting the most precise rejections, with false discovery rate (FDR) control. This is the case, for example, when researchers are interested both in individual hypotheses as well as group hypotheses corresponding to intersections of sets of the original hypotheses, at several resolution levels. A concrete application is in genome-wide association studies, where, depending on the signal strengths, it might be possible to resolve the influence of individual genetic variants on a phenotype with greater or lower precision. To adapt to the unknown signal strength, analyses are conducted at multiple resolutions and researchers are most interested in the more precise discoveries. Assuring FDR control on the reported findings with these adaptive searches is, however, often impossible. To design a multiple comparison procedure that allows for an adaptive choice of resolution with FDR control, we leverage e-values and linear programming. We adapt this approach to problems where knockoffs and group knockoffs have been successfully applied to test conditional independence hypotheses. We demonstrate its efficacy by analysing data from the UK Biobank.</p>
2 Authors
- Paula Gablenz
- Chiara Sabatti
1 Application
| Application ID | Title |
|---|---|
| 27837 | Statistical Methods for Large Scale Genetic Studies |
Enabling scientific discoveries that improve human health