Title: | Cardiovascular health, infection burden, and incident dementia in the UK Biobank |
Journal: | Alzheimer's & Dementia |
Published: | 7 Aug 2023 |
Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37547953/ |
DOI: | https://doi.org/10.1002/alz.13405 |
Title: | Cardiovascular health, infection burden, and incident dementia in the UK Biobank |
Journal: | Alzheimer's & Dementia |
Published: | 7 Aug 2023 |
Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37547953/ |
DOI: | https://doi.org/10.1002/alz.13405 |
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
INTRODUCTION: Among older adults, total and hospitalized infection may be associated with incidence of all-cause and Alzheimer's disease (AD) dementias, with variation by cardiovascular health (CVH).</p>
METHODS: We used Cox proportional hazards (PH) models to examine the relationships between International Classification of Diseases-10th revision (ICD-10)-specific viral and bacterial infectious agents and incident all-cause and AD dementia among 355,046 UK Biobank participants ≥50 years at baseline. Life's Essential 8 (LE8) index reflected CVH.</p>
RESULTS: In both sexes, total infection burden (yes vs. no) was associated with all-cause dementia, with significant interactions by LE8 tertiles, whereby this relationship was significant only in the lowest LE8 tertile. Hospital-treated infection burden (yes vs no) was significantly related to all-cause and AD dementia, with no significant interaction with LE8 tertile. Age group patterns were detected.</p>
DISCUSSION: AD and all-cause dementia were related to hospital-treated infections, while CVH modified the relationship of total infection burden with all-cause dementia. Highlights Secondary analysis on >355,000 UK Biobank participants ≥50 years at baseline. Alzheimer's disease and all-cause dementia are both related to hospital-treated infection. Cardiovascular health modifies association of infection burden with all-cause dementia.</p>
Application ID | Title |
---|---|
77963 | Dissecting racial/ethnic disparities in dementia traits through socio-economic, lifestyle, cardio-metabolic risk and infectious agents, with focus on Helicobacter pylori sero-positivity |
Enabling scientific discoveries that improve human health