| Application: | 24494, Mediating mechanisms linking anthropometric, lifestyle and dietary risk factors with cancer risk |
| Title: | Evaluation of the New Individual Fatty Acid Dataset for UK Biobank: Analysis of Intakes and Sources in 207,997 Participants |
| Size: | 492.7 MB |
| Archived: | 3 May 2024 |
| Stability: | Complete |
| Personal: | Contains individual-level data |
Return 2380
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Notes
The UK Biobank has collected information about participants' diet using the 'Oxford WebQ'. The Oxford WebQ is an online questionnaire, where participants were asked what they consumed the day before. This study describes how participant intakes of individual fatty acids were calculated from the Oxford WebQ using food composition data from the UK and US. These intakes have been compiled into a new 'individual fatty acid dataset', which includes different types of saturated, monounsaturated, and polyunsaturated fatty acids. Palmitic and stearic acid were the main types of saturated fatty acids, and the main sources of these were cereals and cereal products (mostly desserts/cakes/pastries), milk and milk products (mostly cheese and milk), and meat and meat products. Oleic acid was the main monounsaturated fatty acid, derived mostly from cereals and cereal products, and meat and meat products. Linoleic acid was the main polyunsaturated fatty acid, derived mostly from cereals and cereal products, and vegetables (including potatoes) and vegetable dishes. The individual fatty acid dataset for the Oxford WebQ will allow UK Biobank researchers to conduct future investigations on individual fatty acids and disease risk. Kelly RK, Pollard Z, Young H, Piernas C, Lentjes M, Mulligan A, Huybrechts I, Carter JL, Key TJ, Perez-Cornago A. Evaluation of the New Individual Fatty Acid Dataset for UK Biobank: Analysis of Intakes and Sources in 207,997 Participants. Nutrients. 2022 Aug 31;14(17):3603. doi: 10.3390/nu14173603.Application 24494
Mediating mechanisms linking anthropometric, lifestyle and dietary risk factors with cancer risk
The mediating mechanisms linking anthropometric and lifestyle risk factors with cancer development and survival remain unclear. We aim to investigate the potential mediating roles of metabolic factors (including biomarkers and intermediate conditions and diseases) on the association between risk factors (e.g. fat mass, diet, physical activity) and subsequent cancer diagnosis, death and survival by cancer type. The proposed project aims to understand the mechanisms that underpin the association of risk factors with cancer development and progression, which is consistent with UK Biobank's mission of health-related research that is in the interest of the public good. In the first stage of this project we will run prospective analyses to assess the associations of potential risk factors with risk of, and death from, specific cancers. If there are sufficient cases and available information on tumour characteristics, we will split tumours into subtypes. We will also assess the association between the potential risk factors and each of the possible mediators, as well as the prospective associations between the mediators and cancer risk. Finally, we will estimate the mediation effects of the individual mediators in the associations between risk factors and cancer risk. We intend to include all participants of the UK Biobank cohort.
| Lead investigator: | Dr Aurora Perez-Cornago |
| Lead institution: | University of Oxford |
4 related Returns
| Return ID | App ID | Description | Archive Date |
|---|---|---|---|
| 3602 | 24494 | Circulating Insulin-like Growth Factor-I Concentrations and Risk of 30 Cancers: Prospective Analyses in UK Biobank | 29 Jun 2021 |
| 4423 | 24494 | Description of the updated nutrition calculation of the Oxford WebQ questionnaire and comparison with the previous version among 207,144 participants in UK Biobank | 27 Jun 2022 |
| 3604 | 24494 | Health impacts and environmental footprints of diets that meet the Eatwell Guide recommendations: analyses of multiple UK studies | 29 Jun 2021 |
| 3603 | 24494 | Meat intake and cancer risk: prospective analyses in UK Biobank | 29 Jun 2021 |
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