| Title: | Explore the associations of lifestyle and psychosocial factors with neurodegenerative diseases, cardiovascular events, and cancer. |
| Lead Institution: | Huazhong University of Science and Technology |
| Principal investigator: |
Application 89844
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About
The US and European guidelines place greater emphasis on managing these traditional lifestyles to reduce the risk of disease. Despite all the efforts, neurodegenerative diseases, cardiovascular diseases, and tumors are increasing dramatically. Emerging lifestyle factors and psychosocial factors deserve further study for their association with neurodegenerative diseases, cardiovascular diseases, and tumors risk. Patients with dementia often have a combination of cardiovascular disease, dementia and cardiovascular diseases share common risk factors and interact to promote disease progression. However, the evidence is insufficient and the detailed mechanisms are not clear. The UK Biobank dataset gives researchers a platform to conduct these studies. This dataset is characterized by its large size, high quality assessment of lifestyle and psychosocial factors, and longitudinal follow-up of health outcomes. Using the dataset, we aim to investigate the following questions: (1) What is the relationship between individual lifestyle, healthy lifestyle scores and neurodegenerative disease, cardiovascular disease, and cancer? The UK Biobank gives researchers access to individual medical records, which means we can explore the impact of lifestyle on health outcomes. (2) What is the relationship between mental health factors (e.g., nerves, anxiety, tension, and depression) and neurodegenerative disease, cardiovascular disease, and cancer? We can further determine differences in these associations by socioeconomic indicators. (3) Combining an individual's healthy lifestyle score and psychosocial behaviors, we use methods such as machine learning to predict the incidence of health outcomes. For those who are predicted to be at high risk, we advocate managing lifestyle and psychosocial behaviors to reduce the risk of the disease. (4) Patients with neurodegenerative diseases often have a combination of cardiovascular disease. Evidence that neurodegenerative and cardiovascular diseases share common risk factors and interact with each other needs to be further validated in large prospective studies. This project included several sub-analyses that required several collaborators to work together, we expect the project duration of 36 months. This study will improve our understanding of healthy lifestyles and psychosocial factors to create relevant public health guidance. Evidences on the common risk factors and bidirectional relationship between neurodegenerative diseases and cardiovascular events may contribute to future clinical intervention and facilitate the formation of new therapeutic strategies.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 15234 | The relationship of fish oil supplements and plasma fatty acids with lung function decline | Zhilin Zheng (+17) | 2025 | European Journal of Nutrition |
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