| Title: | Integrative Neurobiological Bases of Brain Aging in Late Life |
| Lead Institution: | Harvard University |
| Principal investigator: | Professor Randy Buckner |
Application 67237
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About
Even in the absence of neurodegenerative disorders like dementia or Alzheimer's disorder, aging is associated with changes in the brain as well as deficits in cognitive ability. However, brain aging does not occur at the same pace or in the same way for all individuals. Some may age "optimally" with little to no changes in memory or cognition, while others may experience severe forms of impairment. This project aims to identify factors that are most important for maintaining brain health through late adulthood. We will study individual differences in genetics, lifestyle, and environment in combination with measures of brain shape, size and function. By characterizing which factors are most important for promoting longevity, this work will help craft public health policy and identify specific biological targets for medical research and intervention. This study is expected to last a minimum of three years (2020-2023).1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 16393 | DunedinPACNI estimates the longitudinal Pace of Aging from a single brain image to track health and disease | Ethan T. Whitman (+15) | 2025 | Nature Aging |
Enabling scientific discoveries that improve human health