| Title: | Associations between NR3C1 variants and metabolic phenotypes in humans |
| Lead Institution: | Cincinnati Children's Hospital Medical Center |
| Principal investigator: | Dr Mattia Quattrocelli |
Application 65846
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
About
Glucocorticoid steroids are widely used drugs to manage inflammation in many conditions. Chronic intake of these drugs promotes untoward side effects, like osteoporosis, obesity, growth suppression and hypertension. These steroids act through a receptor called glucocorticoid receptor, encoded by the gene NR3C1. This 3-year-long project aims at evaluating whether genetic variants in this gene correlate with alterations of metabolism or function. The results of this study may pave the way to better understand how we respond to these drugs and how we can counteract their side effects.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 16390 | The human glucocorticoid receptor variant rs6190 increases blood cholesterol and promotes atherosclerosis | Hima Bindu Durumutla (+10) | 2025 | Journal of Clinical Investigation |
Enabling scientific discoveries that improve human health