| Title: | A Genome-Wide Association Study of Tinnitus to Identify Genes of Interest and Potential Therapeutic Targets |
| Lead Institution: | Creighton University |
| Principal investigator: | Dr Jian Zuo |
Application 57266
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About
Tinnitus is a distressing and persistent condition in a wide portion of the population, but little is known about its functioning and direct cause. Without a solid foundation of understanding, it becomes incredibly difficult to develop effective treatments. In order to develop drug therapies for tinnitus, then, it is critical to understand its mechanism of action. To do this, we plan to conduct a genetic study based on data from both the UK Biobank and the U.S. Department of Veteran Affairs to identify genes impacting the development and severity of tinnitus. Then, by relating these genes back to their corresponding pathways and validating the change in activity of these pathways in between healthy and tinnitus-affected individuals, we can identify potential targets for tinnitus therapies. Using a data-based drug screen, it is possible to identify compounds that change the activity of these targets, and by extension, alter the effects of tinnitus in an individual. We are then able to test these compounds in a mouse model that corresponds to the cause of tinnitus, which may be better representative of the effectiveness of the drug against a known cause of tinnitus.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 4933 | Genetic predisposition to tinnitus in the UK Biobank population | Madeleine E. Urbanek (+1) | 2021 | Scientific Reports |
Enabling scientific discoveries that improve human health