| Title: | Assessing risks and prognoses for ocular and chronic systemic illnesses |
| Lead Institution: | Nanchang University |
| Principal investigator: |
Application 564893
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About
The research project is meticulously crafted to explore the complex realm of ocular diseases, recognizing their profound impact on global health, which includes contributing to visual impairment and blindness, and imposing a substantial societal burden. Existing epidemiological and clinical research has established connections between ocular diseases and systemic factors, while genetic studies have highlighted a genetic contribution. However, the interplay with environmental factors remains a significant area of uncertainty. The extensive dataset from the UK Biobank offers an unparalleled opportunity to analyze these intricate relationships. Through the application of various statistical methodologies and the adjustment for confounding variables, our research aims to enhance our understanding of the etiology of ocular diseases, potentially leading to innovative preventive and therapeutic approaches that can mitigate the burden of these conditions. Initially, our focus is on investigating the impact of systemic conditions such as diabetes, hypertension, autoimmune disorders, and cardiovascular diseases on the onset, progression, and severity of a range of ocular conditions, including glaucoma, cataracts, macular degeneration, diabetic retinopathy, hypertensive retinopathy, and retinopathy of prematurity. Subsequently, we intend to examine the complex interplay between genetic predispositions and environmental factors, such as smoking, diet, and physical activity, in the causation of ocular diseases. Finally, we seek to identify robust and clinically applicable biomarkers that can facilitate early detection, precise diagnosis, and personalized interventions.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 20425 | Nonlinear Associations of Estimated Glucose Disposal Rate With Incident Age-Related Eye Diseases: Implications for Metabolic Risk Stratification | Haoyu Yuan (+4) | 2026 | Investigative Ophthalmology & Visual Science |
Enabling scientific discoveries that improve human health