| Title: | Correlation and causal relationship of Blood lipids and metabolites, healthy lifestyle and socioeconomic status with prevalence and mortality of metabolic disease. |
| Lead Institution: | Peking Union Medical College Hospital (PUMCH) |
| Principal investigator: |
Application 479734
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
About
Metabolic diseases, such as diabetes, cardiovascular disease, gout, and metabolic syndrome, represent a significant global health burden. The interplay between blood lipids, metabolites, lifestyle factors, and socioeconomic status (SES) is complex and multifactorial. Elevated blood lipids and altered metabolites are well-established risk factors for metabolic diseases, yet their interaction with lifestyle behaviors (e.g., diet, physical activity, smoking) and SES remains inadequately explored. Understanding these relationships is critical for developing targeted interventions to reduce the incidence and mortality of metabolic diseases. Objectives: 1. To evaluate the correlation between blood lipids, metabolites, and metabolic disease prevalence and mortality. 2. To assess the impact of healthy lifestyle factors (e.g., diet, physical activity, smoking cessation) on the relationship between blood lipids and metabolic disease outcomes. 3. To investigate the role of SES in modulating the relationship between blood lipids, metabolites, and metabolic disease outcomes. 4. To explore potential causal relationships using advanced statistical and machine learning techniques, such as Mendelian randomization and causal inference models.2 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 16320 | Baseline 25-hydroxyvitamin D as a stronger protector against type 2 diabetes in the context of hyperuricemia and gout: a cohort study based on the UK biobank | Yingdong Han (+7) | 2025 | The Journal of Nutritional Biochemistry |
| 16050 | Uric acid and sudden cardiac arrest: a more significant intermediate role of renal insufficiency than cardiac events | Yingdong Han (+7) | 2025 | Heart Rhythm |
Enabling scientific discoveries that improve human health