| Title: | Integrating genetic and multimodal data to enhance understanding and risk prediction of blinding eye diseases |
| Lead Institution: | Eye & ENT Hospital of Fudan University |
| Principal investigator: |
Application 360934
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About
This research project aims to use state-of-the-art techniques to compare genetic, protein, metabolite, and gut bacteria profiles between individuals with and without major blinding eye diseases like glaucoma, AMD, inherited retinal degeneration, retinal dystrophy, diabetic retinopathy, and cataract. By analyzing these factors together, we hope to identify unique biological signatures to enhance our understanding, prediction, and prevention of these conditions. We will utilize data from the UK Biobank, a large study that collected detailed health and biological information from over 500,000 UK adults. Our focus will be on a subset of approximately 50,000 participants with available genetic, protein, metabolite, and gut bacteria data. By comparing this information between individuals with the eye diseases (cases) and those without (controls), we aim to pinpoint key differences contributing to the development of these conditions. This approach seeks to uncover potential biological markers and mechanisms for better prevention and treatment strategies. Advanced statistical and machine learning methods will be employed to analyze the complex data and build models that can discriminate between cases and controls based on their profiles. We will also explore how these factors interact with each other and other known risk factors, such as age and medical history. The project is expected to last four years. By understanding the biological differences between people with and without these blinding eye diseases, we hope to pave the way for new targeted prevention and treatment strategies. The identification of distinctive biomarkers could enable earlier detection and personalized interventions, potentially saving the eyesight of millions worldwide. Given the immense personal and societal costs of blindness, this research has the potential to make a significant public health impact. The UK Biobank provides a unique resource for this cutting-edge research. Its combination of detailed biological data and comprehensive health information makes it possible to study the complex factors underlying these eye diseases using a powerful case-control design. The findings from this project could transform our understanding of eye health, bringing us closer to a future where blindness can be prevented or effectively treated based on an individual's specific biological profile. By leveraging this extensive dataset, we aim to uncover novel insights that could lead to personalized medical approaches and significantly improve outcomes for individuals at risk of blinding eye diseases.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 17459 | Plasma Proteomic Dynamics Preceding Glaucoma Reveal a 15-Year Pre-Diagnostic Window: Causal Insights and Predictive Utility in 45,850 Participants | Yingke Zhao (+8) | 2026 | Investigative Ophthalmology & Visual Science |
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