| Title: | Dissecting the polygenic architecture of non-communicable diseases and comorbidities |
| Lead Institution: | University of Patras |
| Principal investigator: |
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About
Chronic diseases, also known as non-communicable diseases (NCDs), are a leading cause of global health issues, especially with aging populations. Understanding the interplay between the genetic components of NCDs, as well as environmental and heritable risk factors that govern multimorbidity is crucial for effective prevention measures and tailored treatment approaches. Our study aims to disentangle the patterns, outcomes, and predictors of NCDs and multimorbidity using a rich database of epidemiological and genomic data for more than 400.000 individuals of European ancestry. With advanced genetic epidemiology methods, this project shall inform the mechanisms that link exposure factors and heritable background to NCDs, as well as the genetic liability to NCDs with discrete disease domains. By identifying shared risk factors and pathological mechanisms, we hope to improve predictive models and inform targeted interventions. This research could help us develop better treatment strategies that focus on multiple health issues at once, ultimately contributing to advancements in precision medicine approaches.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 15227 | Polygenic transcriptome risk scores enhance predictive accuracy in atopic dermatitis | Charalabos Antonatos (+9) | 2025 | Journal of Translational Medicine |
Enabling scientific discoveries that improve human health