| Title: | Development of a Statistical Method for heritability for X Chromosome Inactivation |
| Lead Institution: | Seoul National University |
| Principal investigator: |
Application 285388
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About
Our study aims to improve our understanding of the X chromosome and its role in complex trait through X-chromosome-specialized statistical methods. The X chromosome is unique and has different properties compared to other chromosomes. In females, one of the two X chromosomes is randomly turned off to achieve a balance with males. However, this process, known as X chromosome inactivation, can cause variations in genetic effects between males and females. To address these complexities, we will develop a new statistical method that considers the inactivation profile of the X chromosome. By incorporating extra information (e.g. gene expression, degree of relativeness) from the X chromosome, we can estimate the effect sizes of genetic variants unbiased and with better statistical power. This study will span up to 3 years, during which we will analyze various complex traits and identify consistent genetic effects across sexes. Through this study, we aim to discover new genetic associations and loci that are specific to the X chromosome. This will provide valuable insights into the underlying genetic mechanisms of complex traits and diseases.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 16387 | BIGFAM - variance components analysis from relatives without genotype | Jaeeun Jerry Lee (+1) | 2025 | Nature Communications |
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