| Title: | From Cardiometabolic diseases to Infectious Diseases: Unraveling the relationship between Healthy Lifestyles and Enhanced Immune Function |
| Lead Institution: | Leiden University Medical Centre |
| Principal investigator: |
Application 242500
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About
The emergence of COVID-19 in 2019 has resurfaced infectious diseases as a significant global public health concern, reminiscent of a century ago. Notably, pre-existing cardiometabolic conditions have been linked to heightened severity of COVID-19 symptoms, highlighting a convergence of underlying disease mechanisms between cardiometabolic and infectious diseases. As we face this new epidemiological transition characterized by the dual challenges of cardiometabolic and infectious diseases, it becomes crucial to identify strategies that target both simultaneously. Diet, exercise, and sleep represent three pivotal modifiable risk factors in combating cardiometabolic diseases. Extensive research has unveiled the anti-inflammatory potential of improving these individual risk factors, effectively boosting the immune system and reducing the risks associated with various diseases. In this study, our objective is to investigate the intricate interactions between dietary patterns, exercise routines, and sleep habits, with a focus on their impact on the immune system and subsequent disease risks. Through this three-year study, our objective is to establish robust causal associations between modifiable risk factors, such as dietary patterns, and immune function. By uncovering these causal links, we aim to provide valuable evidence that can inform future intervention studies aimed at reducing the risk of diseases, particularly among individuals at high risk due to metabolic syndromes. This research has the potential to contribute significantly to the development of targeted interventions and preventive strategies that can enhance immune function and mitigate the impact of diseases in vulnerable populations.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 16313 | Metabotype identification via fasting and postprandial metabolomics and its association with type 2 diabetes incidence | Keyong Deng (+9) | 2025 | Cardiovascular Diabetology |
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