| Title: | Determine the association between bone mineral density and the risk of dementia |
| Lead Institution: | Perron Institute for Neurological and Translational Science |
| Principal investigator: |
Application 199603
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About
Aims: Our main goals are to find out if there's a connection between osteoporosis and the likelihood of experiencing dementia later in life. Additionally, we want to explore whether bone health at different locations in the body (like the spine, hip, and forearm) is linked to the risk of developing late-life dementia. Finally, we'll check if including bone health data improves our ability to predict dementia accurately. Scientific rationale: Osteoporosis, a common condition in older individuals, involves lower bone density, raising the risk of fractures in various body parts. Dementia, especially Alzheimer's disease (AD), affects a significant number of older adults. Both osteoporosis and dementia share increasing age as a major risk factor, and studies suggest a possible connection between bone density and dementia. Some evidence even hints that people with osteoporosis might be more likely to develop AD later in life. However, it's still unclear if bone density is directly linked to the chances of developing dementia. Project duration: Our project is expected to take about 3 years from gathering data to obtaining results. Impact: Dementia is a growing global concern with widespread social and economic effects. Currently, around 50 million people worldwide live with dementia, and this number is predicted to triple by 2050. The challenge is that there can be up to a 20-year period before symptoms appear, making early identification crucial for effective prevention strategies. Our study aims to provide evidence about the relationship between osteoporosis and dementia. Importantly, if our findings show that bone health can predict dementia, it could encourage early lifestyle modifications to support both bone and brain health.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 16202 | Association of heel bone mineral density with incident dementia among ageing adults: a population-based study from the UK Biobank | Jun Lu (+7) | 2025 | Aging Clinical and Experimental Research |
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