| Title: | Exploring the Interaction between Common Neurodegenerative Diseases and Peripheral Metabolic Disorders Based on Epidemiology, Genomics, and Imaging Genomics |
| Lead Institution: | Tongji University School of Medicine |
| Principal investigator: |
Application 194287
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About
This research project focuses on the increasing global issue of neurodegenerative diseases and metabolic disorders, particularly in the aging population. Studies suggest a link between metabolic issues and diseases like Alzheimer's and Parkinson's, with the possibility that one may worsen the other. Animal studies have hinted at genetic factors, oxidative stress, and gut health playing a role in this interaction. To dig deeper, we plan to use the extensive data from the UK Biobank, including information about diseases, genes, and images. Our goals include understanding the relationship between neurodegenerative diseases and metabolic disorders, identifying important genetic factors, and exploring how these conditions affect the brain. This project could lead to crucial insights into preventing and treating these debilitating diseases. By studying a large cohort of participants, the researchers aim to uncover associations, estimate risks, and explore genetic and brain-related aspects of these conditions. Overall, the project strives to enhance our understanding and pave the way for innovative therapeutic approaches.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 20597 | Atlas of human brain imaging-derived phenotypes and disease risk | Qidong Liu (+11) | 2026 | Med |
Enabling scientific discoveries that improve human health