| Title: | Analysis of the composition of blood immune cells in blood clot of large artery atherosclerosis |
| Lead Institution: | Yonsei University |
| Principal investigator: |
Application 177007
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About
Aims: The aim of this research is to explore the blood profile, including metabolite levels, of ischemic stroke patients with different underlying causes. Specifically, we will investigate how the transcriptomic profiles of macrophages in blood clots vary depending on the etiology of the stroke. We also aim to understand how blood cholesterol levels influence macrophage activity in these patients. Scientific Rationale: Ischemic stroke, caused by a blockage in the blood vessels supplying the brain, can result from various underlying conditions. Recent findings suggest that the immune cell composition within blood clots differs based on the cause of the stroke. Our preliminary research has shown distinct gene expression profiles of macrophages in clots from different etiologies. Macrophages play a crucial role in stroke pathology, and their activity is known to be influenced by blood cholesterol levels, as seen in foamy macrophages in atherosclerosis plaques. By investigating the blood profiles of stroke patients, we hope to uncover how cholesterol and other metabolites affect macrophage behavior and contribute to stroke outcomes. Project Duration: This project is expected to take three years to complete, including data analysis, interpretation, and dissemination of findings. Public Health Impact: Understanding the relationship between blood metabolites and macrophage activity in ischemic stroke patients could lead to significant advancements in stroke diagnosis, treatment, and prevention. By identifying specific metabolic profiles associated with different stroke etiologies, we can develop targeted therapies to modulate macrophage activity, potentially improving recovery and reducing the risk of recurrent strokes. This research has the potential to enhance personalized medicine approaches for stroke patients, ultimately improving public health outcomes and reducing the burden of this debilitating condition.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 16764 | Spatial Myeloid Landscape of Large Artery Atherosclerotic and Cardioembolic Thrombi Retrieved by Mechanical Thrombectomy | Sugyeong Jo (+8) | 2025 | The FASEB Journal |
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