| Title: | Integrating phenotypic and multi-omics data to comprehensively explore the potential molecular mechanisms of the interaction between metabolites and lifestyle behaviors in chronic kidney disease |
| Lead Institution: | Shandong University |
| Principal investigator: |
Application 143463
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
About
CKD has emerged as an urgent global public health challenge. Previous studies have reported numerous genetics, lifestyle behaviors, environment, and other risk factors for CKD risk. However, limited literature is available for causal effects of these exposures on CKD and other related chronic diseases risk. Considering the huge heterogeneity in the underlying biological mechanisms of CKD, individuals showed great difference on disease presentation, progression and response to therapy. With the development of high-throughput sequencing technology, multi-omics strategy has become an important tool for biomarker screening and molecular mechanism digging. The integration of multi-omics data might help us to comprehensively understanding of the molecular underpinnings of CKD to improve the care of high-risk population. Therefore, this current study was designed to evaluate the causal effects of lifestyle behaviors on CKD and other related chronic diseases risk for intervention and prevention, with a particular emphasis on the complex interactions of genetic and environmental factors. By integrating multi-omics data, we further aim to explore the role of metabolites in the causal path for lifestyle behaviors to CKD risk. Previous research has elucidated the potential significance of genetics, lifestyle, environment, and other factors in the onset of CKD. However, the intricate interplay and interdependencies among these factors remain not fully understood. Our study strives to meticulously investigate the underlying determinants of CKD and related chronic conditions, with a particular emphasis on the complex interactions of genetic and environmental factors. Furthermore, the molecular mechanisms underlying the development of CKD and related chronic conditions are currently unclear. By integrating multi-omics data from the UK Biobank, we aim to uncover their potential molecular mechanisms. This endeavor aims to enhance our comprehension of the mechanistic basis of disease progression, ultimately providing precise targeted recommendations for future public health policies. The project is anticipated to span a three-year duration, with profound implications for public health on the horizon. Primarily, through an exhaustive exploration of the pathogenesis underlying CKD, we aspire to unveil novel biomarkers conducive to early CKD diagnosis and prevention, thereby extending to the realm of other related chronic diseases. Additionally, by unraveling the intricate involvement of genetic and environmental determinants, we aim to provide personalized health recommendations tailored to high-risk individuals, thereby mitigating disease incidence. Ultimately, the outcomes of this investigation are poised to furnish a pivotal foundation for the formulation of public health policies aimed at alleviating the burden posed by CKD and related chronic conditions.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 12796 | Habitual Iron Supplementation Associated with Elevated Risk of Chronic Kidney Disease in Individuals with Antihypertensive Medication | Xiaoyan Ma (+9) | 2024 | Nutrients |
Enabling scientific discoveries that improve human health