| Title: | The association of healthy lifestyle factors with the risk of rheumatic and musculoskeletal diseases |
| Lead Institution: | Shanghai Sixth People's Hospital |
| Principal investigator: |
Application 141529
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
About
Aims: The benefits of healthy lifestyle are well established, but it is unclear whether these factors are associated with rheumatic and musculoskeletal diseases, such as osteoarthritis, tendinopathy, rheumatoid arthritis, and osteoporosis. This research aimed to conduct a comprehensive analysis of a combination of modifiable, healthy lifestyle factors in the UK Biobank to identify the association of these factors with the rheumatic and musculoskeletal diseases. So that we can protect against common rheumatic and musculoskeletal diseases. Scientific rationale: We will use the data from the UK Biobank to examine the risk of several musculoskeletal diseases (osteoarthritis, rheumatoid arthritis, axial spondylarthritis, psoriatic arthritis, systemic lupus erythematosus, systemic sclerosis, gout, tendinopathy, and osteoporosis) associated with individual and combined lifestyle factors (smoking, alcohol consumption, body mass index, physical activity, and diet). Baseline lifestyle-related factors and covariate information will be based on interviewer-administered questionnaires and physical measurements. A simple low-risk lifestyle score was derived based on the number of low-risk lifestyle factors, ranging from 0 to 5, with higher scores indicating a healthier lifestyle. To enable a phenome-wide investigation, we used ICD-10 codes to categorize musculoskeletal diseases. Project duration: This project is expected to be completed in 36 months. Public health impact: The potential public health impact that will come from this research will relate to an increased understanding of how simple lifestyle changes can create a lasting impact on rheumatic and musculoskeletal diseases (RMDs). We will be able to explain the potential improvements in health and outcomes that can be achieved from healthy lifestyle (smoking, alcohol consumption, body mass index, physical activity, and diet). It is hoped that our study will be educational and encourage people to adopt the healthy lifestyles.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 15091 | Inflammatory Bowel Disease and Risk of Rheumatoid Arthritis: A UK Biobank Cohort Study | Kuangyu He (+8) | 2025 | International Journal of Rheumatic Diseases |
Enabling scientific discoveries that improve human health