| Title: | Environmental risk factors of non-cancer illness |
| Lead Institution: | University of Exeter |
| Principal investigator: | Dr Jess Tyrrell |
Application 1383
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
About
Research at the European Centre for Environment and Human Health (ECEHH) focuses on the complex interconnectedness between human health and the environment. The World Health Organisation estimates that 24% of the global burden of disease and 23% of all deaths are attributable to environmental factors. The epidemiology team within ECEHH investigates both the positive and negative impact of the environment on human health. The researchers associated with this proposal are specifically interested in the role of the environment in non-cancer illnesses, especially asthma, atopic diseases, cardiovascular disease and Meniere?s disease. The UK Biobank provides a unique opportunity for us to investigate the role of broad range of environmental factors in the aetiology of these diseases, in the largest UK based population study, with large numbers of cases and controls. A greater understanding of these diseases is important for improving treatment regimens and public health interventions. Whilst a broad range of factors will be investigated, we have a number of discrete research questions: 1. Does eczema in childhood increases an individual?s likelihood of developing asthma in later life. 2. Does sun exposure influence the incidence of atopic diseases? 3. What factor(s) predispose an individual to Meniere?s disease and how does this disease impact on quality of life? We will utilise a range of statistical techniques to investigate these questions using the baseline data from all participants in the UK Biobank. The initial analysis of the baseline data will allow a better understanding of the data, hypothesis generation for future research and an improved understanding of factors that influence these diseases.5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 8410 | Associations of Leg Length, Trunk Length, and Total Adult Height With Ménière's | Jessica S. Tyrrell (+3) | 2015 | Ear & Hearing |
| 8453 | Gene-obesogenic environment interactions in the UK Biobank study | Jessica Tyrrell (+16) | 2017 | International Journal of Epidemiology |
| 8411 | Mental Health and Subjective Well-being of Individuals With Ménière's | Jessica Tyrrell (+6) | 2015 | Otology & Neurotology |
| 8405 | Prevalence, Associated Factors, and Comorbid Conditions for Ménière's Disease | Jessica S. Tyrrell (+4) | 2014 | Ear & Hearing |
| 8426 | The Cost of Ménière's Disease | Jessica Tyrrell (+2) | 2016 | Ear & Hearing |
Enabling scientific discoveries that improve human health