| Title: | An Integrated Approach to Understanding the Complexity of Brain Disorders for Precision Medicine Development |
| Lead Institution: | Juntendo University |
| Principal investigator: |
Application 135200
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About
Currently, most neurodegenerative and psychiatric disorders are mainly treated symptomatically as no fundamental cure has been established, but the effectiveness of this treatment is limited and varies greatly from person to person. This is due to the fact that the onset and progression of neurological diseases can be influenced not only by genetic factors but also by environmental factors. Furthermore, the mechanisms by which diseases known to adversely affect multiple organs including the brain, such as cancer, lifestyle-related diseases, and COVID-19, cause cognitive dysfunction, as well as their relationship to genetic and environmental factors, have not yet been fully investigated. To address this challenge, this project proposes an integrated approach to simulate the complexity of brain disorders and ultimately support the development of precision medicine. The significance of this project is in accordance with the objectives of UK Biobank. In conclusion, this research project proposes an integrated approach to determine the complexities of brain disorders. By combining diverse data modalities, this research project aims to identify critical factors that influence disease development and determine disease comorbidity patterns. The findings of this study are expected to have significant implications for the advancement of precision medicine in the treatment of brain disorders. This study will be supported by the Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI; Grant numbers 23H02865). The research period is planned to be 36 months.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 15402 | Are Diffusion Models Effective Good Feature Extractors for MRI Discriminative Tasks? | Binghua Li (+11) | 2025 | Magnetic Resonance in Medical Sciences |
Enabling scientific discoveries that improve human health