| Title: | A Study of influencing factors for cerebrovascular and neurodegenerative diseases |
| Lead Institution: | Jinan University |
| Principal investigator: |
Application 104830
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About
Aims: Our aim is to explore the association between influencing factors (including biochemical indices, plasma metabolites, lifestyle, environmental factors and genetic factors) and the incidence and progression of cerebrovascular and neurodegenerative diseases, and investigate the association of influencing factors and the images of brain diseases. Scientific rationale: Cerebrovascular and neurodegenerative diseases are important public health issues worldwide, causing serious morbidity, mortality and economic burden. Despite extensive previous research efforts, the influencing factors of these diseases remain incompletely understood. We propose a study to identify modifiable and non-modifiable influencing factors for cerebrovascular and neurodegenerative disease using the UK Biobank data. By identifying these factors, we hope to improve our understanding of the pathogenesis of cerebrovascular and neurodegenerative disease, and contribute to the development of more effective prevention and treatment strategies. Project duration: This project is expected to last for 36 months. Public health impact: By identifying key contributing factors, public health policies can be developed to help mitigate the incidence, ultimately improving population health outcomes and reducing the economic burden associated with cerebrovascular and neurodegenerative diseases.5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 15856 | Association of worrier trait with the risk of Parkinson's disease: a longitudinal study based on 457,180 UK Biobank participants | Rui Li (+5) | 2025 | Frontiers in Psychology |
| 15062 | Associations of Estimated Glucose Disposal Rate With Stroke Risk and Poststroke Adverse Outcomes: A Prospective Cohort Study | Xiaxuan Huang (+8) | 2025 | CNS Neuroscience & Therapeutics |
| 16316 | Associations of cardiometabolic multimorbidity with all-cause dementia, alzheimer's disease, and vascular dementia: a cohort study in the UK biobank | Junrun Zhang (+6) | 2025 | BMC Public Health |
| 15840 | Exploring the Link Between C-Reactive Protein Change and Stroke Risk: Insights From a Prospective Cohort Study and Genetic Evidence | Yitong Ling (+12) | 2025 | Journal of the American Heart Association |
| 16580 | Periodontal disease is associated with increased stroke risk, an association partially mediated by inflammation. | Yitong Ling (+10) | 2025 | International Journal of Stroke |
Enabling scientific discoveries that improve human health