| Title: | Identification of shared risk factors and gene-environment interactions for cardiometabolic diseases and cardiometabolic multimorbidity |
| Lead Institution: | Suzhou Municipal Hospital |
| Principal investigator: |
Application 104283
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About
Cardiometabolic diseases, including type 2 diabetes, hypertension, dyslipidemia, and cardiovascular diseases, are the predominant non-communicable chronic diseases, causing heavy economic and medical burden worldwide. With the rapid aging of population, cardiometabolic multimorbidity, the coexistence of at least two of cardiometabolic diseases in a person, has become a common phenomenon. To date, it is still a lack of evidence of the shared risk factors and gene-environment interaction for individual cardiometabolic diseases and cardiometabolic multimorbidity. The proposed research aims to identify the shared risk factors, such as lifestyle factors, environment pollution, genetic background, and metabolic factors, and the interactions between these factors for cardiometabolic diseases and cardiometabolic multimorbidity. The expected value of this study will contribute to the prevention and control of cardiometabolic diseases and cardiometabolic multimorbidity and provide scientific evidence to guide health care. In the metabolomic analysis of cardiometabolic multimorbidity, our results will be important in understanding the potential mechanisms of cardiometabolic multimorbidity and provide scientific evidence for therapeutic targets. We plant to apply for the whole cohort, and the proposed duration is 3 years.4 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 16295 | Association between metabolic-associated fatty liver disease and risk of cardiometabolic multimorbidity: a disease trajectory analysis in UK Biobank | Yaqian Gao (+7) | 2025 | Frontiers in Endocrinology |
| 15895 | Associations of Frailty Status and Sleep Quality With Incident Delirium: A Prospective Study in the UK Biobank | Yueqing Huang (+7) | 2025 | CNS Neuroscience & Therapeutics |
| 16300 | Associations of different insulin resistance-related indices with the incidence and progression trajectory of cardiometabolic multimorbidity: a prospective cohort study from UK biobank | Zhenyu Tian (+5) | 2025 | Cardiovascular Diabetology |
| 16111 | Differential associations of dietary inflammatory potential, antioxidant capacity, and Mediterranean diet adherence with biological aging: A UK Biobank study | Cong Zhang (+3) | 2025 | The journal of nutrition, health & aging |
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