| Title: | Incident allergic diseases in post-COVID-19 condition: multinational cohort studies from South Korea, Japan and the UK |
| Journal: | Nature Communications |
| Published: | 2 Apr 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38565542/ |
| DOI: | https://doi.org/10.1038/s41467-024-47176-w |
| URL: | https://www.nature.com/articles/s41467-024-47176-w.pdf |
Publication 9978
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Abstract
As mounting evidence suggests a higher incidence of adverse consequences, such as disruption of the immune system, among patients with a history of COVID-19, we aimed to investigate post-COVID-19 conditions on a comprehensive set of allergic diseases including asthma, allergic rhinitis, atopic dermatitis, and food allergy. We used nationwide claims-based cohorts in South Korea (K-CoV-N; n = 836,164; main cohort) and Japan (JMDC; n = 2,541,021; replication cohort A) and the UK Biobank cohort (UKB; n = 325,843; replication cohort B) after 1:5 propensity score matching. Among the 836,164 individuals in the main cohort (mean age, 50.25 years [SD, 13.86]; 372,914 [44.6%] women), 147,824 were infected with SARS-CoV-2 during the follow-up period (2020−2021). The risk of developing allergic diseases, beyond the first 30 days of diagnosis of COVID-19, significantly increased (HR, 1.20; 95% CI, 1.13−1.27), notably in asthma (HR, 2.25; 95% CI, 1.80−2.83) and allergic rhinitis (HR, 1.23; 95% CI, 1.15−1.32). This risk gradually decreased over time, but it persisted throughout the follow-up period (≥6 months). In addition, the risk increased with increasing severity of COVID-19. Notably, COVID-19 vaccination of at least two doses had a protective effect against subsequent allergic diseases (HR, 0.81; 95% CI, 0.68−0.96). Similar findings were reported in the replication cohorts A and B. Although the potential for misclassification of pre-existing allergic conditions as incident diseases remains a limitation, ethnic diversity for evidence of incident allergic diseases in post-COVID-19 condition has been validated by utilizing multinational and independent population-based cohorts.</p>
12 Authors
- Jiyeon Oh
- Myeongcheol Lee
- Minji Kim
- Hyeon Jin Kim
- Seung Won Lee
- Sang Youl Rhee
- Ai Koyanagi
- Lee Smith
- Min Seo Kim
- Hayeon Lee
- Jinseok Lee
- Dong Keon Yon
1 Application
| Application ID | Title |
|---|---|
| 94075 | Genetic and environmental risk factors for poor respiratory health in adults: comparison of two mega-cohorts in different countries (Korea and UK). |
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